重组人脑利钠肽联合阿司匹林治疗老年顽固性心力衰竭的效果及对患者心功能指标的影响  

Effect of recombinant human brain natriuretic peptide combined with aspirin in the treatment of elderly patients with refractory heart failure and its influence on cardiac function indexes

作　　者：雒番阳 姚瑶 刘文莉[1] 郭亚妮 LUO Fanyang;YAO Yao;LIU Wenli;GUO Yani(Cardiovascular Endocrinology Department,Shaanxi Second People's Hospital,Xi'an 710005,China)

机构地区：[1]陕西省第二人民医院心血管内分泌科,陕西西安710005

出　　处：《临床医学研究与实践》2022年第26期31-33,共3页Clinical Research and Practice

摘　　要：目的 探讨重组人脑利钠肽联合阿司匹林治疗老年顽固性心力衰竭的效果及对患者心功能指标的影响。方法 选取2018年1月至2020年5月我院收治的150例老年顽固性心力衰竭患者,以抽签法随机将其分为对照组和观察组,各75例。对照组采用常规治疗+阿司匹林,观察组在对照组基础上联合重组人脑利钠肽治疗。比较两组的临床疗效。结果 观察组的治疗总有效率为93.33%,高于对照组的81.33%(P<0.05)。治疗后,观察组的左室射血分数(LVEF)高于对照组,左室舒张末期内径(LVEDD)及左室收缩末期内径(LVESD)小于对照组(P<0.05)。治疗后,观察组的乳酸脱氢酶(LDH)、心肌肌钙蛋白I(cTnI)、肌酸激酶同工酶(CK-MB)及心脏型脂肪酸结合蛋白(H-FABP)水平均低于对照组(P<0.05)。结论 重组人脑利钠肽联合阿司匹林治疗老年顽固性心力衰竭不仅能提高治疗效果,也能促进患者心功能改善,减轻心肌损伤,值得推广。Objective To explore the effect of recombinant human brain natriuretic peptide combined with aspirin in the treatment of elderly patients with refractory heart failure and its influence on cardiac function indexes.Methods A total of150 elderly patients with refractory heart failure admitted in our hospital from January 2018 to May 2020 were selected and randomly divided into control group and observation group by lottery method,with 75 cases in each group.The control group was given conventional treatment + aspirin,and the observation group was treated with recombinant human brain natriuretic peptide on the basis of the control group.The clinical effects of the two groups were compared.Results The total effective rate of treatment of the observation group was 93.33%,which was higher than 81.33% of the control group(P<0.05).After treatment,the left ventricular ejection fraction(LVEF) of the observation group was higher than that of the control group,and the left ventricular end diastolic diameter(LVEDD) and left ventricular end systolic diameter(LVESD) were smaller than those of the control group(P <0.05).After treatment,the levels of lactic dehydrogenase(LDH),cardiac troponin I(cTnI),creatine kinase isoenzymes-MB(CK-MB) and heart-type fatty acid-binding protein(H-FABP) in the observation group were lower than those in the control group(P<0.05).Conclusion The recombinant human brain natriuretic peptide combined with aspirin in the treatment of elderly patients with refractory heart failure can not only improve the treatment effect,but also promote the improvement of cardiac function and reduce the myocardial damage,which is worth promoting.

关 键 词：重组人脑利钠肽 阿司匹林 顽固性心力衰竭 心功能 心肌损伤 

分 类 号：R541.6[医药卫生—心血管疾病]