Examining patterns of traditional chinese medicine use in pediatric oncology: A systematic review, meta-analysis and data-mining study  

作　　者：Chun Sing Lam Li Wen Peng Lok Sum Yang Ho Wing Janessa Chou Chi-Kong Li Zhong Zuo Ho-Kee Koon Yin Ting Cheung 

机构地区：[1]School of Pharmacy,Faculty of Medicine,the Chinese University of Hong Kong,Hong Kong,China [2]Department of Paediatrics,Faculty of Medicine,the Chinese University of Hong Kong,Hong Kong,China [3]Hong Kong Hub of Paediatric Excellence,the Chinese University of Hong Kong,Hong Kong,China [4]Department of Paediatrics&Adolescent Medicine,Hong Kong Children’s Hospital,Hong Kong,China [5]School of Chinese Medicine,Faculty of Medicine,the Chinese University of Hong Kong,Hong Kong,China

出　　处：《Journal of Integrative Medicine》2022年第5期402-415,共14页结合医学学报（英文版）

摘　　要：Background Traditional Chinese medicine(TCM)is becoming a popular complementary approach in pediatric oncology.However,few or no meta-analyses have focused on clinical studies of the use of TCM in pediatric oncology.Objective We explored the patterns of TCM use and its efficacy in children with cancer,using a systematic review,meta-analysis and data mining study.Search strategy We conducted a search of five English(Allied and Complementary Medicine Database,Embase,PubMed,Cochrane Central Register of Controlled Trials,and ClinicalTrials.gov)and four Chinese databases(Wanfang Data,China National Knowledge Infrastructure,Chinese Biomedical Literature Database,and VIP Chinese Science and Technology Periodicals Database)for clinical studies published before October 2021,using keywords related to“pediatric,”“cancer,”and“TCM.”Inclusion criteria We included studies which were randomized controlled trials(RCTs)or observational clinical studies,focused on patients aged<19 years old who had been diagnosed with cancer,and included at least one group of subjects receiving TCM treatment.Data extraction and analysis The methodological quality of RCTs and observational studies was assessed using the six-item Jadad scale and the Effective Public Healthcare Panacea Project Quality Assessment Tool,respectively.Meta-analysis was used to evaluate the efficacy of combining TCM with chemotherapy.Study outcomes included the treatment response rate and occurrence of cancer-related symptoms.Association rule mining(ARM)was used to investigate the associations among medicinal herbs and patient symptoms.Results The fifty-four studies included in this analysis were comprised of RCTs(63.0%)and observational studies(37.0%).Most RCTs focused on hematological malignancies(41.2%).The study outcomes included chemotherapy-induced toxicities(76.5%),infection rate(35.3%),and response,survival or relapse rate(23.5%).The methodological quality of most of the RCTs(82.4%)and observational studies(80.0%)was rated as“moderate.”In studies of

关 键 词：Traditional Chinese Medicine Herbal medicine Pediatric oncology Data mining Associate rule mining CHEMOTHERAPY 

分 类 号：R273[医药卫生—中西医结合]