内生菌影响药用植物产生药理活性化合物的研究进展  

Impact of Endophytic Microorganisms on the Pharmaco-active Compounds Production in Medicinal Plants:A Review

作　　者：张昊[1] 刘苗苗 刘晓娜[1] 李宗谕 赵丽丽 杨清香[1] ZHANG Hao;LIU Miao-miao;LIU Xiao-na;LI Zong-yu;ZHAO Li-li;YANG Qing-xiang(College of Life Sciences,Henan International Joint Laboratory of Agricultural Microbial Ecology and Technology,Henan Normal University,Xinxiang 453007)

机构地区：[1]河南师范大学生命科学学院河南省农业微生物生态与技术国际联合实验室,新乡453007

出　　处：《生物技术通报》2022年第8期41-51,共11页Biotechnology Bulletin

基　　金：国家自然科学基金项目(U1504219);河南省高等学校重点科研项目计划(20A180015);河南师范大学博士启动课题资助项目(5101049170183);新乡市科技攻关项目(GC2020006)。

摘　　要：药用植物自古以来就被应用于传统医学,是抗菌、抗病毒、抗肿瘤等天然药物的重要来源。广泛存在于植物健康组织中的内生微生物,是植物微生态系统的重要组成部分。已有研究表明,大量药用植物内生菌具有重要的生物学价值和经济意义,它们在漫长的进化过程中,与宿主植物之间建立了某些特殊的关系,对药用植物活性代谢产物的形成有重要作用,进而影响药用植物源药材的质量和产量。本文聚焦于内生菌与药用植物药效成分之间的相互关系,通过调查近年来已发表的药用植物内生菌研究数据,总结了存在于药用植物中的内生菌多样性、潜在药用价值、影响药理活性化合物生成的生物学机制问题。本综述旨在阐明内生菌在天然药物生产中的作用机制和重要地位,了解相关知识有助于科研工作者更有效的利用植物内生菌控制药材品质,或者从植物/内生菌资源中开发、生产更多更好的天然药物。Medicinal plants have been used in traditional medicine since antiquity,and they represent a very important source of natural medicines such as antimicrobial,antiviral,and antitumor molecules.Endophytic microorganisms exist widely inside the healthy tissues of living plants,and are important components of plant micro-ecosystems.In fact,many studies have demonstrated the biological and economic importance of endophytes in medicinal plants.Over the long period of their evolution,these microbes have established some special relationships with their host plants,which can significantly influence the formation of bioactive metabolic products in hosts,then affect the quality and quantity of crude drugs derived from these medicinal plants.This paper focuses on the increasing knowledge of relationships between endophytes and pharmaco-active compounds in medicinal plants through reviewing of the published data of studying endophytes in medical plants in recent years.The analytical results summarize the studies on endophytes isolated from medicinal plants,including their biodiversity,pharmacological potential,and biosynthetic mechanism affecting the formation of pharmaco-active compounds.The aim of this review is to elucidate the role mechanism and importance of endophytes in the production of natural medicines.Understanding such knowledge can help researchers apply them more effectively to improve the quality of medicinal plants,or exploit more and better natural medicines from plants or endophytes resources.

关 键 词：内生菌 药用植物 药理活性化合物 天然药物 

分 类 号：R284[医药卫生—中药学]