DNA甲基化和组蛋白甲基化修饰的表观遗传调控作用研究进展  

Research Progress in the Roles of DNA and Histone Methylations in Epigenetic Regulation

作　　者：张淼 杨露露 贾岩龙[1,2] 王天云[2,3] ZHANG Miao;YANG Lu-lu;JIA Yan-long;WANG Tian-yun(School of Pharmacy,Xinxiang Medical University,Xinxiang 453003;International Joint Research Laboratory for Recombiant Pharmaceutical Protein Expression System of Henan,Xinxiang Medical University,Xinxiang 453003;School of Basic Medicine,Xinxiang Medical University,Xinxiang 453003)

机构地区：[1]新乡医学院药学院,新乡453003 [2]新乡医学院重组药物蛋白表达系统国际联合实验室,新乡453003 [3]新乡医学院基础医学院,新乡453003

出　　处：《生物技术通报》2022年第7期23-30,共8页Biotechnology Bulletin

基　　金：国家自然科学基金项目(32071468);河南省重点研发与推广专项(科技攻关)(192102310149)。

摘　　要：在真核生物中,作为表观遗传调控的常见机制,DNA甲基化和组蛋白甲基化主要影响染色质结构和基因的转录表达,特别是在哺乳动物细胞基因表达调控、维持基因组稳定性等方面起着重要的作用。本文综述了DNA甲基化修饰及其基因表达调控作用;组蛋白甲基化修饰的基因表达调控方式、功能及其研究进展;以及DNA甲基化和组蛋白甲基化在表观遗传调控方面的相互作用。In eukaryotes,as a common mechanism of epigenetic regulation,DNA and histone methylations mainly affect chromatin structure and gene transcription expression,especially in gene expression regulation of mammalian cells and maintaining genome stability.This paper reviews DNA methylation modification and its role in gene expression regulation,gene expression regulation mode,function and research progress of histone methylation modification,as well as the interaction between DNA and histone methylations in epigenetic regulation.

关 键 词：基因表达 表观遗传调控 DNA甲基化 组蛋白甲基化 

分 类 号：Q75[生物学—分子生物学]