银杏叶提取物联合头孢曲松治疗神经性梅毒伴发脑卒中患者的效果分析  

Effect Analysis of Ginkgo Biloba Extract Combined with Ceftriaxone in the Treatment of Neurosyphilis with Stroke

作　　者：徐龙栋 吴敏 徐文[2] 蒋文婷 XU Longdong;WU Min;XU Wen;JIANG Wenting(Department of Neurology,Changshu Fifth People's Hospital,Changshu,Jiangsu Province,215500 China;Department of Dermatology,Changshu Second People's Hospital,Changshu,Jiangsu Province,215500 China;Suzhou Pharmaceutical Association,the Second Affiliated Hospital of Suzhou University,Suzhou,Jiangsu Province,215500 China)

机构地区：[1]常熟市第五人民医院神经内科,江苏常熟215500 [2]常熟市第二人民医院皮肤性病科,江苏常熟215500 [3]苏州大学附属第二医院苏州市药学会,江苏苏州215500

出　　处：《系统医学》2022年第13期5-8,13,共5页Systems Medicine

基　　金：苏州市科技发展计划(SYSD2019182)。

摘　　要：目的探讨银杏叶提取物联合头孢曲松治疗神经性梅毒伴发脑卒中患者的效果。方法选取2018年6月—2021年6月份江苏省常熟市第二人民医院收治的神经性梅毒伴发脑卒中患者76例,按照随机数表法分为常规组(38例)与研究组(38例)。常规组仅给予头孢曲松治疗,研究组在常规组的基础上给予银杏叶提取物治疗。比较治疗前后两组患者的美国国立卫生研究院卒中量表(NIHSS)评分以及认知功能采用智力状态采用简易智能精神状态检查量表(MMSE),治疗效果和不良反应。结果治疗前,两组患者NIHSS、MMSE评分比较差异无统计学意义(P>0.05);4个疗程后,两组NIHSS比治疗前降低,且研究组低于常规组,MMSE评分高于治疗前,且研究组高于常规组,差异有统计学意义(P<0.05);4个疗程后,研究组总有效率为94.74%,高于常规组76.32%,差异有统计学意义(χ^(2)=5.208,P<0.05)。两组患者不良反应对比,研究组不良反应发生率(5.26%)低于常规组(21.05%),差异有统计学意义(P<0.05)。结论银杏叶提取物联合头孢曲松治疗神经性梅毒伴发脑卒中患者,有利于改善患者神经功能状态以及认知功能,提高临床疗效,且安全性好,具有一定的推广应用价值。Objective To investigate the effect of Ginkgo biloba extract combined with ceftriaxone in the treatment of neurosyphilis with stroke.Methods 76 patients with neurosyphilis complicated with stroke treated in the second people's Hospital from June 2018 to June 2021 were randomly divided into routine group(38 cases)and study group(38 cases).The routine group was only given ceftriaxone,and the study group was given Ginkgo biloba extract on the basis of the routine group.The National Institutes of Health Stroke Scale(NIHSS)scores were compared between the two groups before and after treatment.As well as comparing cognitive function using intelligence status using the Mini-Mental State Examination Scale(MMSE),treatment effects and adverse reactions.Results Before treatment,there was no statistically significant difference in NIHSS and MMSE scores between the two groups(P>0.05).After 4 courses of treatment,NIHSS of both groups was lower than before treatment,and the study group was lower than the conventional group,MMSE score was higher than before treatment,and the study group was higher than the conventional group,the difference was statistically significant(P<0.05).After 4 courses of treatment,the total effective rate of the study group was 94.74%,which was higher than that of the conventional group(76.32%),the difference was statistically significant(χ^(2)=5.208,P<0.05).The incidence of adverse reactions in the study group(5.26%)was lower than that in the conventional group(21.05%),and the difference was statistically significant(P<0.05).Conclusion Ginkgo biloba extract combined with ceftriaxone in the treatment of patients with neurosyphilis complicated with stroke is conducive to improve the state of neurological function and cognitive function,improve the clinical efficacy,and has good safety.It has certain popularization and application value.

关 键 词：银杏叶提取物 头孢曲松 神经性梅毒伴发脑卒中 认知功能 临床疗效 

分 类 号：R4[医药卫生—临床医学]