夏橘化瘀胶囊对房颤射频消融术后左房内径及复发的影响  

Effect of Xiajuhuayu Capsule on Left Atrial Diameter and Recurrence of Atrial Fibrillation after Radiofrequency Ablation

作　　者：葛汝青 李杰[1] 许军[1] 李敏 GE Ruqing;LI Jie;Xu Jun;LI Min(Second Department of Cardiology,Weifang Traditional Chinese Medicine Hospital(National Standardized Atrial Fibrillation Center),Weifang,Shandong Province,261000 China)

机构地区：[1]潍坊市中医院(国家标准化房颤中心)心内二科,山东潍坊261000

出　　处：《系统医学》2022年第13期23-26,31,共5页Systems Medicine

基　　金：潍坊市高新技术产业开发区科技惠民项目(2020KJHM36)。

摘　　要：目的探讨夏橘化瘀胶囊对阵发性房颤患者射频消融术后左房内径及早期复发的影响。方法选取2020年12月—2021年8月潍坊市中医院心内科收治的80例行射频消融术的阵发性房颤患者为研究对象,采用随机数表法分为治疗组和对照组,每组40例。对照组先行射频消融术后再服用胺碘酮进行治疗,治疗组则先行射频消融术后再联合服用夏橘化瘀胶囊、胺碘酮进行治疗。观测两组患者手术前及术后3个月左房内径(LAD)、射血分数(LVEF)等心功能指标的变化,测定比较两组患者血清中超敏-C反应蛋白(hs-CRP)以及白细胞介素-6(IL-6)的变化,并根据随访结果统计两组患者房颤复发情况。结果术前两组LAD、LVEF比较,差异无统计学意义(P>0.05),术后3个月两组LAD均降低,LVEF升高,且术后3个月治疗组LAD为(31.56±2.68)mm,低于对照组的(33.63±2.97)mm,LVEF为(65.28±1.24)%,高于对照组的(62.94±1.02)%,差异有统计学意义(t=3.273、9.217,P<0.05)。术前两组hs-CRP、IL-6水平比较,差异无统计学意义(P>0.05);术后3个月两组hs-CRP、IL-6水平均下降,且治疗组的hs-CRP、IL-6水平为(66.21±7.54)ng/L、(69.52±7.66)g/L,均低于对照组的(72.90±9.12)ng/L、(80.91±8.51)g/L,差异有统计学意义(t=3.576、6.292,P<0.05)。治疗组和对照组的术后3个月房颤复发率分别为10.00%、27.50%,治疗组低于对照组,差异有统计学意义(χ^(2)=4.021,P<0.05)。结论夏橘化瘀胶囊能够有效降低阵发性房颤患者射频消融术后左房内径的大小,提高射血分数,改善炎症因子水平,有助于降低术后早期复发率。Objective To investigate the effect of the Xiajuhuayu capsule on the left atrial diameter and early recurrence after radiofrequency ablation in patients with paroxysmal atrial fibrillation.Methods 80 patients with paroxysmal atrial fibrillation who underwent radiofrequency ablation in the Department of Cardiology of Weifang Hospital of traditional Chinese medicine from December 2020 to August 2021 were selected as the research objects.They were randomly divided into treatment group and control group,with 40 cases in each group.The control group was treated with amiodarone after radiofrequency ablation,while the treatment group was treated with Xiajuhuayu capsule and amiodarone after radiofrequency ablation.The changes of left atrial diameter(LAD),ejection fraction(LVEF)and other cardiac function indexes were observed before and 3 months after operation.The changes of serum hs CRP and IL-6 in the two groups were measured and compared.The recurrence of atrial fibrillation in the two groups was calcu-lated according to the follow-up results.Results There was no statistically significant difference in LAD and LVEF between the two groups before operation(P>0.05).At 3 months after operation,LAD decreased and LVEF increased in both groups;at 3 months after operation,the LAD of the treatment group was(31.56±2.68)mm,which was lower than that of the control group(33.63±2.97)mm,and the LVEF was(65.28±1.24))%,higher than the control group(62.94±1.02)%,and the difference was statistically significant(t=3.273,9.217,P<0.05).There was no statistically significant difference in the levels of hs-CRP and IL-6 between the two groups before operation(P>0.05);3 months after operation,the levels of hs-CRP and IL-6 in both groups decreased,and the levels of hs-CRP and IL-6 in the treatment group were(66.21±7.54)ng/L and(69.52±7.66)g/L,which were lower than those in the control group(72.90±9.12)ng/,(80.91±8.51)g/L,and the difference was statistically significant(t=3.576,6.292,P<0.05).The re-currence rate of atrial fibrillation at

关 键 词：夏橘化瘀胶囊 阵发性房颤 左房内径 早期复发 炎症因子 

分 类 号：R59[医药卫生—内科学]