肝功指标、血脂血清学指标水平检验在脂肪肝诊断中的临床价值  

Clinical Value of Liver Function Index and Blood Lipid Serological Index Level Test in the Diagnosis of Fatty Liver

作　　者：杨春香 YANG Chunxiang(Department of Laboratory Medicine,Affiliated Hospital of Jiangnan University,Wuxi,Jiangsu Province,214000 China)

机构地区：[1]江南大学附属医院检验科,江苏无锡214000

出　　处：《系统医学》2022年第13期27-31,共5页Systems Medicine

摘　　要：目的探讨肝功指标、血脂血清学指标诊断脂肪肝的临床价值。方法选取2019年8月—2021年8月江南大学附属医院收治的48例脂肪肝患者作为观察组,另选同期于本院体检的48名无脂肪肝健康者作为对照组。所有患者均采集清晨空腹血5 mL,以全自动分析仪测定丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、总胆固醇(TC)、三酰甘油(TG)水平。比较两组肝功指标、血脂血清学指标阳性率,并比较不同程度脂肪肝血清学指标水平变化及各指标诊断效能。结果观察组ALT、AST、TC、TG水平为(66.95±5.52)U/L、(69.85±6.14)U/L、(6.35±1.12)mmol/L、(2.35±0.34)mmol/L,高于对照组,差异有统计学意义(t=45.848、41.708、11.182、13.111,P<0.05);重度脂肪肝患者ALT(74.38±5.79)U/L、AST(77.89±6.04)U/L、TC(7.13±0.82)mmol/L、TG(2.63±0.25)mmol/L>中度患者>轻度患者,差异有统计学意义(F=52.320、58.709、11.621、68.037,P<0.05);观察组ALT、AST、TC、TG及联合检测阳性率为64.58%、62.50%、54.17%、56.25%、91.67%,高于对照组,差异有统计学意义(χ^(2)=35.704、36.750、21.010、27.927、60.271,P<0.05);联合检测灵敏度、准确度高于ALT、AST、TC、TG任意一项单独检测,差异有统计学意义(P<0.05)。结论肝功指标、血脂血清学指标联合检验可提高脂肪肝诊断灵敏度、准确度,利于尽早发现疾病,并予以相应治疗,且上述指标与脂肪肝严重程度呈正比。Objective To investigate the clinical value of liver function indexes and blood lipid serological indexes in the diagnosis of fatty liver.Methods A total of 48 fatty liver patients admitted to Affiliated Hospital of Jiangnan University from August 2019 to August 2021 were selected as the observation group,and 48 healthy people without fatty liver who underwent physical examination in the hospital during the same period were selected as the control group.5 mL of fasting blood was collected from all patients in the morning,and the levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST),total cholesterol(TC)and triacylglycerol(TG)were measured by automatic analyzer.The positive rates of liver function indexes,blood lipid serological indexes were compared between the two groups,and the changes of serological indexes of different degrees of fatty liver and the diagnostic efficiency of each index were compared.Results The levels of ALT,AST,TC and TG in the observation group were(66.95±5.52)U/L,(69.85±6.14)U/L,(6.35±1.12)mmol/l,(2.35±0.34)mmol/l,which were significantly higher than those in the control group,the difference was statistically significant(t=45.848,41.708,11.182,13.111,P<0.05);in patients with severe fatty liver,ALT(74.38±5.79)U/L,AST(77.89±6.04)U/L,TC(7.13±0.82)mmol/L,TG(2.63±0.25)mmol/L>moderate patients>mild patients,the difference was statistically significant(F=52.320,58.709,11.621,68.037,P<0.05);the positive rates of ALT,AST,TC and TG and combined tests in the observation group were 64.58%,62.50%,54.17%,56.25%and 91.67%,which were significantly higher than those in the control group,the difference was statistically significant(χ^(2)=35.704,36.750,21.010,27.927,60.271,P<0.05);the sensitivity and accuracy of combined detection were higher than that of ALT,AST,TC and TG alone,the difference was statistically significant(P<0.05).Conclusion The combined test of liver function indexes and blood lipid serological indexes can improve the sensitivity and accuracy of the diagnosis of fa

关 键 词：脂肪肝 肝功指标 血脂指标 血清学指标 临床诊断 应用价值 

分 类 号：R521[医药卫生—内科学]