促甲状腺激素对多囊卵巢综合征患者糖脂代谢及生殖内分泌功能的影响  

Effects of Thyroid Stimulating Hormone on Glucose and Lipid Metabolism and Reproductive Endocrine Function in Patients with Polycystic Ovary Syndrome

作　　者：赵欣华 ZHAO Xinhua(Department of Obstetrics and Gynecology,Pingyi County People's Hospital,Linyi,Shandong Province,273300 China)

机构地区：[1]平邑县人民医院妇产科,山东临沂273300

出　　处：《系统医学》2022年第13期166-169,189,共5页Systems Medicine

摘　　要：目的研究促甲状腺激素对多囊卵巢综合征患者糖脂代谢及生殖内分泌功能的影响。方法本次纳入2019年7月—2020年6月在平邑县人民医院门诊就诊的76例多囊卵巢综合征患者展开研究,按照随机数表法进行分组。对照组38例予以二甲双胍单药治疗,观察组38例在其基础上联合促甲状腺激素治疗。将两组的糖脂代谢指标、生殖内分泌功能、临床疗效进行比对。结果观察组治疗后的FPG(4.24±0.25)mmol/L、FINS(9.01±0.76)mU/L、TC(4.00±0.34)mmol/L、TG(0.80±0.10)mmol/L、HOMA-IR(1.30±0.32)均低于对照组,差异有统计学意义(t=10.063、18.442、6.267、28.664、10.579,P<0.05)。超重和肥胖患者的FPG(4.85±0.48)mmol/L、FINS(20.25±3.40)mU/L、TC(5.24±0.72)mmol/L、TG(1.75±0.37)mmol/L、HOMA-IR(2.37±0.46)高于体质量正常者,差异有统计学意义(t=6.163、14.223、6.353、7.924、11.313,P<0.05)。观察组治疗后的FSH(2.65±0.50)IU/L、LH(15.30±1.92)IU/L、T(7.14±0.76)ng/L水平低于对照组,E2(98.53±9.34)ng/L、治疗总有效率(97.37%)高于对照组,差异有统计学意义(t=12.167、10.928、14.506、9.493,χ^(2)=4.537,P<0.05)。结论在多囊卵巢综合征患者治疗中加用促甲状腺激素能够更好地调节糖脂代谢和生殖内分泌功能,还可减轻胰岛素抵抗,疗效显著。Objective To study the effect of thyroid stimulating hormone on glucose and lipid metabolism and reproductive endocrine function in patients with polycystic ovary syndrome.Methods This study included 76 patients with polycystic ovary syndrome who visited the outpatient clinic of Pingyi County People’s Hospital from July 2019 to June 2020.According to the random number table method,38 cases in the control group were treated with metformin monotherapy,and 38 cases in the observation group were treated with thyroid-stimulating hormone on this basis.The glucose and lipid metabolism indexes,reproductive endocrine function and clinical efficacy of the two groups were compared.Results After treatment,the FPG(4.24±0.25)mmol/L,FINS(9.01±0.76)mU/L,TC(4.00±0.34)mmol/L,TG(0.80±0.10)mmol/L,HOMA-IR(1.30±0.32)were lower than the control group,and the difference was statistically significant(t=10.063,18.442,6.267,28.664,10.579,P<0.05).FPG(4.85±0.48)mmol/L,FINS(20.25±3.40)mU/L,TC(5.24±0.72)mmol/L,TG(1.75±0.37)mmol/L,HOMA-IR(2.37±0.46)in overweight and obese patients higher than those of normal weight,and the difference was statistically significant(t=6.163,14.223,6.353,7.924,11.313,P<0.05).After treatment,the levels of FSH(2.65±0.50)IU/L,LH(15.30±1.92)IU/L,and T(7.14±0.76)ng/L in the observation group were lower than those in the control group,and the E2 after treatment(98.53±9.34)ng/L and the total effective rate of treatment(97.37%)were higher than those of the control group,and the difference was statistically significant(t=12.167,10.928,14.506,9.493,χ^(2)=4.537,P<0.05).Conclusion The addition of thyroidstimulating hormone to the treatment of patients with polycystic ovary syndrome can better regulate glucose and lipid metabolism and reproductive endocrine function,and can also reduce insulin resistance,with a significant effect.

关 键 词：多囊卵巢综合征 促甲状腺激素 糖脂代谢 生殖内分泌功能 

分 类 号：R4[医药卫生—临床医学]