导火汤加味辅助治疗小儿疱疹性口炎脾胃积热型43例临床观察  

Clinical observation on 43 cases of herpes stomatitis in children with accumulating heat of spleen and stomach type adjuvantly treated by modified Daohuo Tang(导火汤)

作　　者：丁盛 厉彬曙 方芳 DING Sheng;LI Binshu;FANG Fang(Department of Stomatology,Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine,Wenzhou,Zhejiang,325000,China;Department of Pediatrics,Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine,Wenzhou,Zhejiang,325000,China)

机构地区：[1]温州市中西医结合医院口腔科,浙江温州325000 [2]温州市中西医结合医院中医儿科,浙江温州325000

出　　处：《中医儿科杂志》2022年第4期70-73,共4页Journal of Pediatrics of Traditional Chinese Medicine

基　　金：浙江省中医药科技计划项目(2018ZB124)。

摘　　要：目的 观察导火汤加味辅助治疗小儿疱疹性口炎脾胃积热型的临床疗效。方法 选取2019年7月至2020年7月在温州市中西医结合医院口腔科和中医儿科就诊的疱疹性口炎脾胃积热型患儿86例,按照随机数字表法分为对照组和治疗组,各43例。对照组予开喉剑喷雾剂(儿童型)口腔局部喷雾、阿昔洛韦片口服,治疗组在对照组治疗方法的基础上内服导火汤加味,2组均治疗7 d后统计疗效。结果 治疗组热退时间、疼痛流涎消失时间、溃疡消退时间均显著短于对照组,2组比较,差异有统计学意义(P<0.05)。治疗组总有效率为97.67%(42/43),对照组为81.40%(35/43),2组比较,差异有统计学意义(P<0.05)。治疗前,2组血清C-反应蛋白(CRP)和肿瘤坏死因子-α(TNF-α)水平比较,差异无统计学意义(P>0.05),具有可比性;治疗后2组血清CRP和TNF-α水平均明显下降,与同组治疗前比较,差异有统计学意义(P<0.01),且治疗组下降更显著(P<0.05)。2组在治疗过程中,均未见明显不良反应发生。结论 导火汤加味辅助治疗小儿疱疹性口炎脾胃积热型,不仅能明显缓解临床症状,抑制炎症反应,疗效显著,而且无明显不良反应,值得临床推广应用。Objective To observe the clinical efficacy of modified Daohuo Tang(导火汤)on herpes stomatitis in children with accumulating heat of spleen and stomach type.Methods From July 2019 to July 2020,86 cases of herpes stomatitis in children with accumulating heat of spleen and stomach type consulted in stomatology and pediatrics departments of Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine were chosen and divided into control group and treatment group by random number table method,with 43 cases in each group.The control group was given oral topical spray of Kaihoujian Penwuji(Ertongxing)and oral administration of aciclo⁃vir tablets,on this basis,the treatment group was given oral administration of modified Daohuo Tang.We kept statis⁃tics about the curative effects after the 2 groups were both treated for 7 days.Results The time of fever abatement,disappearance time of pain and salivation and the time to ulcer resolution in the treatment group were significantly shorter than those in the control group,and the difference was statistically significant between the 2 groups(P<0.05).The total effective rate of the treatment group was 97.67%(42/43),that of the control group was 81.40%(35/43),and the difference was statistically significant between the 2 groups(P<0.05).Before treatment,the differ⁃ences were not statistically significant in serum levels of C⁃reactive protein(CRP)and tumor necrosis factor⁃α(TNF⁃α)between the 2 groups(P>0.05),indicating comparability.After treatment,the serum levels of CRP and TNF⁃αin the 2 groups both significantly decreased,and the differences were statistically significant than the same group before treatment(P<0.01),moreover,the decrease was more significant in the treatment group(P<0.05).During the treatment,no significant adverse reactions were found in both groups.Conclusion It can not only markedly alleviate the clinical symptoms and inhibit the inflammatory reactions with marked efficacy,but also have no marked adverse reactions to use modifie

关 键 词：疱疹性口炎 小儿 脾胃积热型 导火汤 临床观察 

分 类 号：R272.6[医药卫生—中医儿科学]