哌拉西林钠他唑巴坦钠致速发型过敏反应  

Immediate‑type hypersensitivity induced by piperacillin sodium and tazobactam sodium

作　　者：胡晓玲[1] 牛亚珍 崔亚登 王帅 Hu Xiaoling;Niu Yazhen;Cui Yadeng;Wang Shuai(Department of Pharmacy,Heping Hospital Affiliated to Changzhi Medical College,Shanxi Province,Changzhi 046000,China)

机构地区：[1]长治医学院附属和平医院药剂科,长治046000

出　　处：《药物不良反应杂志》2022年第8期437-438,共2页Adverse Drug Reactions Journal

摘　　要：1例75岁男性患者因肺部感染接受哌拉西林钠他唑巴坦钠4.5 g静脉滴注、2次/d。首次用药15 min后,患者双侧上肢皮肤出现红色斑块伴瘙痒,同时出现胸闷、憋气,查体示心率110次/min,呼吸26次/min,血压196/118 mmHg(1mmHg=0.133kPa),血氧饱和度0.85。考虑为哌拉西林钠他唑巴坦钠所致速发型过敏反应。停用该药,给予糖皮质激素和平喘等对症治疗;2 h后患者皮肤瘙痒程度减轻,红斑颜色变浅,胸闷、憋气症状缓解,查体示心率100次/min,血压150/90 mmHg,血氧饱和度0.90。A 75yearold male patient with pulmonary infection received an IV infusion of piperacillin sodium and tazobactam sodium 4.5 g twice daily.Fifteen minutes after the first medication,the patient developed patches on the skin of both upper limbs with pruritus,chest tightness and suffocation.Physical examination showed heart rate 110 beats/min,breathing rate 26 breaths/min,blood pressure 196/118 mmHg,and oxygen saturation 0.85.Immediatetype hypersensitivity related to piperacillin sodium and tazobactam sodium was considered.The drug was discontinued and symptomatic treatments including glucocorticoids and antiasthma were given.Two hours later,the skin itching was alleviated,the color of erythema became lighter,and the symptoms of chest tightness and suffocation were relieved.Physical examination showed that the heart rate was 100 beats/min,the blood pressure was 150/90 mmHg,and the blood oxygen saturation was 0.90.

关 键 词：过敏反应 药物相关副作用和不良反应 哌拉西林 

分 类 号：R969[医药卫生—药理学]