盐酸多柔比星脂质体注射液致手足综合征  

Hand‑foot syndrome caused by doxorubicin hydrochloride liposome injection

作　　者：张智琪[1] 高杰[1] Zhang Zhiqi;Gao Jie(Department of Pharmacy,First Affiliated Hospital of Soochow University,Jiangsu Province,Suzhou 215006,China)

机构地区：[1]苏州大学附属第一医院药学部,苏州215006

出　　处：《药物不良反应杂志》2022年第8期439-441,共3页Adverse Drug Reactions Journal

摘　　要：1例58岁女性乳腺癌患者行单侧乳腺改良根治术后给予环磷酰胺+盐酸多柔比星脂质体注射液方案化疗2次,化疗前均给予地塞米松注射液5 mg预处理,每次化疗后都出现不同程度的黏膜溃疡,双手、双足红肿,症状呈加重趋势,但几天后均自行好转。第3次化疗后患者双手、双足红肿伴水疱渗液,体温升高,最高达40.0℃,背部出现大片红斑,腋下红斑伴糜烂渗出,口腔黏膜溃疡。考虑患者手足综合征的可能性大,予甲泼尼龙琥珀酸钠、头孢西丁钠、奥美拉唑等药物治疗,呋喃西林溶液湿敷患处及保持皮肤湿润等外部皮肤护理措施。治疗15 d后患者手足症状好转。后期停用盐酸多柔比星脂质体注射液,改用多西他赛治疗,手足症状未再出现。A 58‑year‑old female patient with breast cancer received cyclophosphamide and doxorubicin hydrochloride liposome injection chemotherapy twice after modified radical mastectomy.The patient was pretreated with dexamethasone injection 5 mg before chemotherapy.After each chemotherapy,mucosal ulcer of different degrees occurred,and both hands and feet were red and swollen,which showed an aggravating trend,but were all improved after a few days.After the 3rd chemotherapy,the patient's hands and feet were red and swollen,accompanied by blisters and exudation,her body temperature rose up to 40.0℃,with large area of erythema on his back,axillary erythema with erosion exudation,and oral mucosal ulcer.It was considered that the patient was likely to have hand‑foot syndrome.Methylprednisolone,cefoxitin,omeprazole,and other drugs,external skin care measures such as wet compress of the affected area with furacilin solution and keeping the skin moist were given.After 15 days of treatments,the patient's hands and feet symptoms were improved.Then doxorubicin hydrochloride liposomes injection were stopped and replaced by docetaxel,and hand and foot symptoms in the patient did not recur.

关 键 词：手足综合征 多柔比星 脂质体 

分 类 号：R969[医药卫生—药理学]