胺碘酮治疗急性心肌梗死后室性心律失常对患者不良反应及QRS波时间的影响  

Impacts of amiodarone on the adverse reactions and QRS wave time of patients with ventricular arrhythmia after acute myocardial infarction

作　　者：许楚伟 林悦涛[1] 刘涛生[1] XU Chuwei;LIN Yuetao;LIU Taosheng(Department of Cardiovascular Internal Medicine,Puning Overseas Chinese Hospital Guangdong,Puning 515300,China)

机构地区：[1]广东省普宁华侨医院心血管内科,广东普宁515300

出　　处：《中国医药科学》2022年第16期152-155,192,共5页China Medicine And Pharmacy

摘　　要：目的探讨胺碘酮治疗急性心肌梗死后室性心律失常对患者不良反应及QRS波时间的影响。方法选取2019年5月至2021年5月广东省普宁华侨医院收治的急性心肌梗死后室性心律失常患者64例,依据随机数表法分为研究组和对照组,每组各32例,两组均采用常规治疗,在此基础上对照组加用利多卡因治疗,研究组加用胺碘酮治疗。比较两组治疗总有效率、QRS波时间、室性心律失常发作次数、不良反应发生率。结果研究组患者治疗后的总有效率为90.63%,高于对照组的78.13%(P<0.05);研究组患者治疗后不良反应发生率为9.37%,低于对照组的18.75%(P<0.05);研究组患者治疗后的QRS波时间、室性心律失常发作次数为(0.08±0.02)s、(79.33±20.5)次,均低于对照组的(0.12±0.01)s、(103.62±10.34)次;两组患者治疗后的LVESD、LVEDD及LVEF比较,差异有统计学意义(P<0.05),其中,研究组患者治疗后的LVEF指标高于对照组,而LVESD、LVEDD指标均低于对照组(P<0.05);两组患者治疗后的BNP、心率、收缩压、舒张压指标比较,差异有统计学意义(P<0.05),其中,研究组患者治疗后的BNP、心率、收缩压、舒张压水平均低于对照组,差异有统计学意义(P<0.05);两组患者治疗后的AngⅡ、MMP-9指标比较,差异有统计学意义(P<0.05),其中,研究组患者治疗后的AngⅡ、MMP-9指标均低于对照组(P<0.05)。结论急性心肌梗死后室性心律失常患者的治疗过程中,胺碘酮能够将患者的不良反应有效降低,同时提高治疗有效率,改善QRS波时间以及室性心律失常发作次数,心功能指标、BNP、心率、收缩压、舒张压水平改善明显。Objective To investigate the impacts of amiodarone on the adverse reactions(ARs)and QRS wave time of patients with ventricular arrhythmia after acute myocardial infarction.Methods A total of 64 patients with ventricular arrhythmia after acute myocardial infarction admitted to and treated in Puning Overseas Chinese Hospital of Guangdong Province from May 2019 to May 2021 were selected as research subjects,and they were divided into the study group(n=32)and the control group(n=32)according to the random number table method.Both groups were treated with conventional therapy.On this basis,the control group was treated with lidocaine,while the study group was treated with amiodarone.The effective rate of treatment,QRS wave time,the onset frequency of ventricular arrhythmia and the incidence of ARs were compared between the two groups.Results After treatment,the overall effective rate in patients in the study group was 90.63%,higher than 78.1%in the control group(P<0.05).The incidence of ARs in patients of the study group was 9.37%,lower than 18.75%of the control group(P<0.05).After treatment,the QRS wave time and the onset frequency of ventricular arrhythmia in patients of the study group were(0.08±0.02)s and(79.33±20.5)times,both lower than(0.12±0.01)s and(103.62±10.34)times of the control group,respectively.After treatment,there were statistically significant differences in left ventricular end-systolic dimension(LVESD),left ventricular end-diastolic dimension(LVEDD)and left ventricular ejection fraction(LVEF)between the two groups of patients(P<0.05),and the LVEF of patients in the study group after treatment was higher than that in the control group,while the LVESD and LVEDD were both shorter than those in the control group(P<0.05).After treatment,there were statistically significant differences in brain natriuretic peptide(BNP),heart rate,systolic blood pressure and diastolic blood pressure between the two groups of patients(P<0.05),and the levels of BNP,heart rate,systolic blood pressure and diastolic blood

关 键 词：胺碘酮 急性心肌梗死 室性心律失常 不良反应 QRS波时间 

分 类 号：R541.7[医药卫生—心血管疾病] R542.22[医药卫生—内科学]