Study on the effect and mechanism of taxifolin on ameliorating cisplatin-induced acute kidney injury in mice through peroxisome proliferator-activated receptorγcoactivator-1α-mediated antioxidant pathway  

作　　者：TIAN Chongmei 田崇梅(Dept Pharm,Shaoxing TCM Hosp,Zhejiang CM Univ,Shaoxing 312000)

机构地区：[1]Dept Pharm,Shaoxing TCM Hosp,Zhejiang CM Univ,Shaoxing 312000

出　　处：《China Medical Abstracts(Internal Medicine)》2022年第2期117-117,共1页中国医学文摘（内科学分册（英文版）

摘　　要：Objective To explore the effect and mechanism of taxifolin (TAX) on ameliorating cisplatin-induced renal oxidative damage.Methods(1) Forty male C57BL/6mice were divided into 4 groups:control group (n=10), TAX group (n=10), cisplatin group (n=10)and cisplatin+TAX group (n=10). The weight of mice in each group was measured. The level of serum creatinine (Scr) and blood urea nitrogen (BUN) was analyzed. Kidney histopathological change in mice was analyzed by HE staining.

关 键 词：C57BL/6 damage Scr 

分 类 号：R285.5[医药卫生—中药学]