肿瘤内科常用药物与复方苦参注射液配伍的稳定性研究  

Study on the Stability of Compatibility of Commonly Used Drugs and Compound Matrine Injection in Oncology Department

作　　者：于然 夏金[1] YU Ran;XIA Jin(Department of Pliative Care,Anyang Cancer Hospital,Anyang 455000,Henan,China)

机构地区：[1]安阳市肿瘤医院姑息治疗科,河南安阳455000

出　　处：《中国药物滥用防治杂志》2022年第7期892-895,共4页Chinese Journal of Drug Abuse Prevention and Treatment

摘　　要：目的:探讨肿瘤内科常用药物与复方苦参注射液配伍的稳定性。方法:模拟临床的给药剂量和方法,将复方苦参注射液分别和肿瘤内科常用药物(亚叶酸钙注射液、托烷司琼注射液、西咪替丁注射液、甲氧氯普胺注射液)进行配伍,并于0、1、3、6 h后对溶液外观、pH值变化以及不溶性微粒数进行统计。结果:复方苦参注射液和西咪替丁、甲氧氯普胺、亚叶酸钙三种成品输注液进行配伍后外观均为澄明,性状良好,且配伍后pH值均无显著变化;但托烷司琼输注液和复方苦参注射液进行配伍后3 h则出现颜色加深以及浑浊沉淀的变化,同时其pH值随着时间的推移逐渐降低,且变化较为明显;西咪替丁、甲氧氯普胺、亚叶酸钙注射液分别和复方苦参注射液进行配伍6 h内,均符合不溶性微粒测定的标准;但托烷司琼注射液和复方苦参注射液进行配伍3 h后≥10μm的不溶性微粒以及配伍6 h后≥25μm的不溶性微粒均不符合标准。结论:复方苦参注射液和托烷司琼注射液配伍后其稳定性较差,不建议临床序贯滴入。Objective:To investigate the stability of compatibility of commonly used drugs in oncology with compound matrine injection.Methods:The dosage and method of clinical administration were simulated,and the compound matrine injection was mixed with the commonly used drugs in the department of oncology(calcium folinate injection,tropisetron injection,cimetidine injection,and metoclopramide injection),respectively.After 0,1,3,and 6 hours,the appearance of the solution,pH changes,and the number of insoluble particles were counted.Results:The appearance of compound matrine injection and cimetidine,metoclopramide and calcium folinate were clear and good,and the pH value had no significant change after compatibility.But tropisetron infusion and compound matrine injection appeared color deepening and turbidity precipitation changes after 3 hours,and the pH value gradually decreased over time,and the change was obvious;cimetidine,metoclopramide and calcium folinate injection were mixed with compound matrine injection for 6 hours,respectively,and they all met the standard for the determination of insoluble particles.However,the insoluble particles of tropisetron injection and compound matrine injection≥10μm after 3 hours and≥25μm after 6 hours did not meet the standard.Conclusion:The stability of compound matrine injection and tropisetron injection is poor after compatibility,and it is not recommended for clinical sequential infusion.

关 键 词：复方苦参注射液 托烷司琼注射液 PH值 不溶性微粒 

分 类 号：R969[医药卫生—药理学]