One-stage revision arthroplasty in a patient with ochronotic arthropathy accompanied by joint infection:A case report  

作　　者：Xiao-Chao Wang Xiao-Min Zhang Wan-Ling Cai Zhen Li Chao Ma Yi-Hai Liu Qi-Lian He Tian-Sheng Yan Xue-Wei Cao 

机构地区：[1]The Second Clinical Medical College,Guangzhou University of Chinese Medicine,Guangzhou 510000,Guangdong Province,China [2]Department of Orthopaedics,Xi’an International Medical Center Hospital,Xi’an 710100,Shaanxi Province,China [3]Department of Surgery,Baoji Hospital of Traditional Chinese Medicine,Baoji 721000,Shaanxi Province,China [4]Department of Orthopaedic Surgery,Guangdong Provincial Hospital of Traditional Chinese Medicine,Guangzhou 510120,Guangdong Province,China

出　　处：《World Journal of Clinical Cases》2022年第25期9036-9043,共8页世界临床病例杂志

基　　金：Supported by Talent Training Project of Guangdong Provincial Bureau of Traditional Chinese Medicine,No.0103030908;Guangdong Provincial Hospital of Traditional Chinese Medicine and the School of Biomedicine,Chinese University of Hong Kong School of Medicine,Basic Clinical Collaborative Innovation Project,No.YN2018HK04。

摘　　要：BACKGROUND Ochronotic arthropathy(OcA)is a rare disease,which is caused by the accumulation of homogentisic acid in the joint.Patients with OcA have obvious joint pain and the disease progresses rapidly,eventually resulting in disability.Arthroplasty is an efficacious treatment in patients with OcA.However,when OcA patients have joint infection,is joint replacement an option?In the present report,we performed total knee arthroplasty in a patient with OcA and knee infection under the guidance of one-stage revision theory.CASE SUMMARY A 64-year-old male was referred to our hospital due to severe left knee pain with limited mobility for 2 years.On physical examination,the patient was found to have dark brown pigmentation of the sclera and auricle.Laboratory test results showed elevations in C-reactive protein level(65.79 mg/L)and erythrocyte sedimentation rate(90.00 mm/h).The patient underwent debridement of the left knee joint,during which the cartilage surface of the knee joint was found to be black-brown in color.Bacterial culture of synovial fluid revealed Achromobacter xylosoxidans.We then carried out arthroplasty under the guidance of the theory of one-stage revision.After surgery,the patient’s left knee joint pain disappeared and function recovered without joint infection.CONCLUSION OcA accompanied by joint infection is rare.One-stage revision arthroplasty may be a treatment option for this disease.

关 键 词：Ochronotic arthropathy Arthroplasty One-stage revision ALKAPTONURIA Homogentisic acid Case report 

分 类 号：R687.4[医药卫生—骨科学]