Tamsulosin-induced life-threatening hypotension in a patient with spinal cord injury:A case report  

作　　者：Jae Young Lee Ho Seok Lee Si-Bog Park Kyu Hoon Lee 

机构地区：[1]Rehabilitation Medicine,Hanyang University Hospital,Seoul 04763,South Korea

出　　处：《World Journal of Clinical Cases》2022年第25期9142-9147,共6页世界临床病例杂志

摘　　要：BACKGROUND Tamsulosin,a selectiveα1-adrenergic receptor antagonist,is commonly used for treating neurogenic bladder in patients with spinal cord injury(SCI).No severe adverse events have been described with such tamsulosin use.To our knowledge,we report the first case of severe life-threatening hypotension as an adverse effect of tamsulosin in a person with SCI.Therefore,we report this case to inform that this severe adverse effect of tamsulosin can occur when treating patients with SCI.CASE SUMMARY A 59-year-old woman was diagnosed with cervical spinal cord myelopathy and was classified as American Spinal Injury Association Impairment Scale D,neurological level of injury C3.Because she suffered from voiding difficulty due to neurogenic bladder,we prescribed tamsulosin.Her vital signs remained stable,but occasional hypotensive symptoms followed defecation.We reduced the dose of tamsulosin,but after administering tamsulosin for 9 d,she experienced lifethreatening hypotension with no evidence of hypovolemic shock,neurogenic shock,cardiogenic shock,or septic shock.A hypotensive condition induced by tamsulosin was the suspected cause,and her symptoms could be associated with adverse effects of tamsulosin.As symptoms resolved after stopping tamsulosin,and no other reason was found,we concluded that tamsulosin was the cause of her symptoms.CONCLUSION Caution for severe hypotension is needed when administering tamsulosin for neurogenic bladder in a patient with SCI.

关 键 词：TAMSULOSIN Neurogenic bladder Spinal cord injury HYPOTENSION Vasovagal symptoms Case report 

分 类 号：R651.2[医药卫生—外科学]