Cefoperazone-sulbactam and ornidazole for Gardnerella vaginalis bloodstream infection after cesarean section:A case report  

作　　者：Yu Mu Jing-Jing Li Xiao Wu Xin-Fang Zhou Lian Tang Qin Zhou 

机构地区：[1]National Clinical Pharmacist Training Base,The Affiliated Suzhou Hospital,Nanjing Medical University/Suzhou Municipal Hospital,Suzhou 215002,Jiangsu Province,China [2]Department of Pharmacy,Xuzhou Maternity and Child Health Hospital/Affiliated Xuzhou Maternity and Child Health Hospital,Xuzhou Medical University,Xuzhou 221000,Jiangsu Province,China [3]Department of Pharmacy,The Affiliated Suzhou Hospital,Nanjing Medical University/Suzhou Municipal Hospital,Suzhou 215002,Jiangsu Province,China [4]Department of Obstetrics,The Affiliated Suzhou Hospital,Nanjing Medical University/Suzhou Municipal Hospital,Suzhou 215002,Jiangsu Province,China

出　　处：《World Journal of Clinical Cases》2022年第26期9323-9331,共9页世界临床病例杂志

摘　　要：BACKGROUND Gardnerella vaginalis(G.vaginalis)is a facultative anaerobic bacteria known to cause bloodstream infections.However,cases are very rare in clinics.There is very limited clinical experience in the treatment of bloodstream infections caused by G.vaginalis.Therefore,there is an urgent need for effective antibacterial drugs to treat patients with bloodstream infections caused by G.vaginalis.CASE SUMMARY A woman who underwent a cesarean section presented with a sudden onset of high fever 1-d post-surgery.The blood cultures suggested an infection due to G.vaginalis,and treatment with cefoperazone-sulbactam was started.After 5 d of treatment,there was a decrease in the hemogram;however,the temperature and C-reactive protein levels remained high.Based on clinical experience and a review of literature,the treatment was modified to include ornidazole in combination with cefoperazone-sulbactam.Following a week of treatment,the temperature,hemogram and C-reactive protein levels returned to normal,and blood cultures turned negative,suggesting a therapeutic effect of the combination treatment.CONCLUSION This case highlighted the effective use of cefoperazone-sulbactam combined with ornidazole for bloodstream infection caused by G.vaginalis following a cesarean section.

关 键 词：Gardnerella vaginalis Bloodstream infections ANTI-INFECTIVE CEFOPERAZONE-SULBACTAM ORNIDAZOLE Case report 

分 类 号：R719.8[医药卫生—妇产科学]