Long-term liver allograft fibrosis:A review with emphasis on idiopathic post-transplant hepatitis and chronic antibody mediated rejection  

作　　者：Mukul Vij Ashwin Rammohan Mohamed Rela 

机构地区：[1]Department of Pathology,Dr.Rela Institute and Medical Center,Chennai 600044,Tamil Nadu,India [2]Institute of Liver disease and Transplantation,Dr.Rela Institute and Medical Center,Chennai 600044,Tamil Nadu,India

出　　处：《World Journal of Hepatology》2022年第8期1541-1549,共9页世界肝病学杂志（英文版）（电子版）

摘　　要：Liver transplantation(LT)is a life-saving surgical procedure and the current standard of care for most patients with end stage liver disease.With improvements in organ preservation techniques,perioperative care,and immunosuppression,there is better patient and graft survival following LT,and assessment of the liver allograft in long-term survivors is becoming increasingly important.Recurrent or de novo viral or autoimmune injury remains the most common causes of chronic hepatitis and fibrosis following liver transplantation in adults.However,no obvious cause can be identified in many adults with controlled recurrent disease and the majority of pediatric LT recipients,as they have been transplanted for non-recurrent liver diseases.Serial surveillance liver biopsies post LT have been evaluated in several adult and pediatric centers to identify long-term pathological changes.Pathological findings are frequently present in liver biopsies obtained after a year post LT.The significance of these findings is uncertain as many of these are seen in protocol liver biopsies from patients with clinically good allograft function and normal liver chemistry parameters.This narrative review summaries the factors predisposing to long-term liver allograft fibrosis,highlighting the putative role of idiopathic post-LT hepatitis and chronic antibody mediated rejection in its pathogenesis.

关 键 词：Liver allograft fibrosis Long term Idiopathic hepatitis Chronic antibody mediated rejection 

分 类 号：R657.3[医药卫生—外科学]