Outcomes of patients with post-hepatectomy hypophosphatemia:A narrative review  

作　　者：Kai Siang Chan Swetha Mohan Vishal G Shelat 

机构地区：[1]Department of General Surgery,Tan Tock Seng Hospital,Singapore 308433,Singapore [2]Lee Kong Chian School of Medicine,Nanyang Technological University,Singapore 308232,Singapore

出　　处：《World Journal of Hepatology》2022年第8期1550-1561,共12页世界肝病学杂志（英文版）（电子版）

摘　　要：Phosphate is an essential electrolyte for proper mineralisation of bone,buffering of urine,and diverse cellular actions.Hypophosphatemia(HP)is a clinical spectrum which range from asymptomatic to severe complications such as neuromuscular and pulmonary complications,or even death.Post-hepatectomy HP(PHH)has been reported to be 55.5%-100%.Post-hepatectomy,there is rapid uptake of phosphate and increased mitotic counts to aid in regeneration of residual liver.Concurrently,PHH may be due to increased urinary phosphorous from activation of matrix extracellular phosphoglycoprotein in the injured liver,which decreases phosphate influx into hepatocytes to sustain adenosine triphosphate synthesis.A literature review was performed on Pub Med till January 2022.We included 8 studies which reported on impact of PHH on post-operative outcomes.In patients with diseased liver,PHH was reported to have either beneficial or deleterious effects on post-hepatectomy liver failure(PHLF),morbidity and/or mortality in various cohorts.In living donor hepatectomy,PHLF was higher in PHH.Benefits of correction of PHH with reduced postoperative complications have been shown.Correction of PHH should be done based on extent of PHH.Existing studies were however heterogenous;further studies should be conducted to assess PHH on post-operative outcomes with standardized phosphate replacement regimes.

关 键 词：HEPATECTOMY Hepatocellular Carcinoma HYPOPHOSPHATEMIA PHOSPHATES Liver neoplasms Liver transplantation 

分 类 号：R657.3[医药卫生—外科学]