Metabolic determinants of stemness in medulloblastoma  

作　　者：Paula Martín-Rubio Pilar Espiau-Romera Alba Royo-García Laia Caja Patricia Sancho 

机构地区：[1]Hospital Universitario Miguel Servet,IIS Aragón,Zaragoza 50009,Spain [2]Department of Medical Biochemistry and Microbiology,Biomedical Center,Uppsala University,Uppsala SE-751,Sweden

出　　处：《World Journal of Stem Cells》2022年第8期587-598,共12页世界干细胞杂志（英文版）（电子版）

基　　金：Supported by the Miguel Servet and pFIS fellowships,No.CP16/00121(P.S.) and No.FI21/00031(P.E-R.) from the Instituto de Salud Carlos Ⅲ and cofinanced by European funds(FSE:“el FSE invierte en tu futuro”);Magnus Bergvalls Stiftelse,No.2021-04284(L.C.);the Ⅳ Grant for Childhood Cancer Research from Asociación de Padres de Niños con Cáncer de Aragón(ASPANOA,P.S.).

摘　　要：Medulloblastomas(MBs)are the most prevalent brain tumours in children.They are classified as grade IV,the highest in malignancy,with about 30%metastatic tumours at the time of diagnosis.Cancer stem cells(CSCs)are a small subset of tumour cells that can initiate and support tumour growth.In MB,CSCs contribute to tumour initiation,metastasis,and therapy resistance.Metabolic differences among the different MB groups have started to emerge.Sonic hedgehog tumours show enriched lipid and nucleic acid metabolism pathways,whereas Group 3 MBs upregulate glycolysis,gluconeogenesis,glutamine anabolism,and glutathione-mediated anti-oxidant pathways.Such differences impact the clinical behaviour of MB tumours and can be exploited therapeutically.In this review,we summarise the existing knowledge about metabolic rewiring in MB,with a particular focus on MB-CSCs.Finally,we highlight some of the emerging metabolism-based therapeutic strategies for MB.

关 键 词：MEDULLOBLASTOMA Cancer stem cells STEMNESS METABOLISM GLYCOLYSIS LIPIDS 

分 类 号：R739.41[医药卫生—肿瘤]