贵州省不同免疫策略时期百日咳报告病例流行病学特征  

Epidemiological characteristics of pertussis cases reported during different immunization strategies in Guizhou province

作　　者：蒋凤[1] 柳江凤 包美玲[2] 唐宁[1] 高源雪 叶新贵[1] Jiang Feng;Liu Jiangfeng;Bao Meiling;Tang Ning;Gao Yuanxue;Ye Xingui(Guizhou Provincial Center for Disease Control and Prevention,Guiyang 550004,Guizhou,China;Guizhou Medical University,Guiyang 550025,Guizhou China)

机构地区：[1]贵州省疾病预防控制中心,贵州贵阳550004 [2]贵州医科大学,贵州贵阳550025

出　　处：《中国疫苗和免疫》2022年第4期407-411,共5页Chinese Journal of Vaccines and Immunization

基　　金：黔科合基础-ZK[2021]一般498;黔科合基础[2019]1185号。

摘　　要：目的比较贵州省不同百日咳疫苗免疫策略时期百日咳流行病学特征。方法通过中国疾病预防控制信息系统收集2005-2020年贵州省百日咳报告病例,比较2005-2007年、2008-2010年、2011-2015年和2016-2020年不同免疫策略时期报告发病率和分布特征。结果2005-2020年贵州省百日咳年均报告发病率(/10万)为0.46(2652例),四个时期分别为0.29(328例)、0.15(171例)、0.13(225例)、1.08(1928例)。在所有病例中,实验室诊断病例比例为55.62%,四个时期分别为0.91%、1.17%、8.89%、75.21%;0岁、1-3岁、4-6岁、7-14岁、≥15岁年均报告发病率(/10万)分别为23.04、2.09、0.69、0.12、0.002,其中0岁病例四个时期分别为6.84、5.09、4.92、61.37。在0岁病例中,0-2、3-5、6-11月龄病例分别占27.09%、44.06%、28.84%。结论近年贵州省人群特别是婴儿百日咳报告发病率呈上升趋势,早期报告发病率可能低于实际水平;建议进一步加强百日咳实验室监测和适龄儿童百日咳疫苗及时全程接种,适时优化免疫程序。Objective To compare epidemiological characteristics of pertussis in Guizhou province during periods with different immunization strategies.Methods We obtained pertussis reports in Guizhou from 2005 to 2020 from the China Disease Prevention and Control Information System.We compared incidences and characteristics of pertussis during different immunization strategy periods of 2005-2007,2008-2010,2011-2015,and 2016-2020.Results The overall annual average reported incidence of pertussis in Guizhou during 2005-2020 was 0.46 per 100000 population(2652 cases),with incidences per 100000 being 0.29(328 cases),0.15(171 cases),0.13(225 cases),and 1.08(1928 cases)in the four periods,respectively.Laboratory-confirmed cases accounted for 55.62%of all reported cases,and for 0.91%,1.17%,8.89%,and 75.21%of cases reported during the four periods.Annual average reported incidences per 100000 for 0-,1-3-,4-6-,7-14-,and≥15-year-olds were 23.04,2.09,0.69,0.12,and 0.002;for<1-year-olds,incidences in the four periods were 6.84,5.09,4.92,and 61.37.Among<1-year-old cases,0-2-,3-5-,and 6-11-month-olds accounted for 27.09%,44.06%,and 28.84%.Conclusions The reported incidence of pertussis,especially among infants,increased in Guizhou in recent periods but may have been underreported in the early periods.We suggest strengthening pertussis laboratory monitoring,ensuring timely full-series vaccination of children,and optimizing the pertussis immunization schedule.

关 键 词：百日咳 流行病学特征 免疫策略 

分 类 号：R186.3[医药卫生—流行病学] R183.3[医药卫生—公共卫生与预防医学]