Probiotic treatment of inflammatory bowel disease:Its extent and intensity  

作　　者：Saheli Biswas Ena Ray Banerjee 

机构地区：[1]Department of Zoology,University of Calcutta,Kolkata 700019,West Bengal,India

出　　处：《World Journal of Immunology》2022年第2期15-24,共10页世界免疫学杂志

摘　　要：Free radicals(reactive oxygen species,superoxides and hydroxyl radicals)lead to the development of oxidative stress because of imbalance in the amount of antioxidants.Continued development of oxidative stress leads to chronic diseases in humans.The instability in the antioxidant activities and accumulation of oxidative stress due to free radicals may occur in diseases like inflammatory bowel disease(IBD).Antioxidants are substances that inhibit or delay the mechanism of oxidation of molecules mediated by free radicals and also transform into lesseractive derivatives.Probiotics are defined as live microorganisms that show beneficial effects on inflamed intestine and balance the inflammatory immune responses in the gut.Probiotic strains have been reported to scavenge hydroxyl radicals and superoxide anions that are abundantly produced during oxidative stress.The most widely studied probiotic strains are Streptococcus,Bifidobacterium and Lactobacillus.Probiotics cultured in broth have shown some amount of antioxidant activities.Fermented milk and soy milk,which possess starter microorganisms(probiotics),tends to increase the antioxidant activities manyfold.This review aims to discuss the in vivo and in vitro antioxidant activities of specific probiotics with various assays with respect to IBD.

关 键 词：Oxidative stress Inflammatory bowel disease PROBIOTICS THERAPY Antioxidative activity 

分 类 号：O62[理学—有机化学]