右美托咪定对兔坐骨神经阻滞时罗哌卡因血药浓度的影响  

Effect of dexmedetomidine on blood concentrations of ropivacaine during sciatic nerve block in rabbits

作　　者：廖淑婷 邹霞 林成新[3] Liao Shuting;Zou Xia;Lin Chengxin(Department of Anesthesiology,the First Clinical Medical College of Guangxi Medical University,Nanning 530021,China;Department of Anesthesiology,the Peoples Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021,China;Department of Anesthesiology,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China)

机构地区：[1]广西医科大学第一临床医学院麻醉科,南宁530021 [2]广西壮族自治区人民医院麻醉科,南宁530021 [3]广西医科大学第一附属医院麻醉科,南宁530021

出　　处：《中华麻醉学杂志》2022年第6期725-727,共3页Chinese Journal of Anesthesiology

基　　金：广西自然科学基金(2016GXNSFAA380299)。

摘　　要：目的评价右美托咪定对兔坐骨神经阻滞时罗哌卡因血药浓度的影响。方法健康新西兰兔12只,雌雄不拘,体重2~3 kg,采用随机数字表法分为罗哌卡因组(R组)和罗哌卡因混合右美托咪定组(RD组),每组6只。2组均在右侧进行股静脉穿刺置管以备采血,R组在左侧坐骨神经旁注射0.375%罗哌卡因3 ml,RD组注射含1.5μg/kg右美托咪定的0.375%罗哌卡因3 ml。于神经阻滞前(T_(0))、神经阻滞后15、30、45、60、120和180 min(T_(1~6))时采集右侧股静脉血样,离心后应用高效液相色谱法测定血浆罗哌卡因浓度,绘制时间-药物浓度曲线。结果与R组比较,RD组T_(1~3)时罗哌卡因血药浓度降低(P<0.05),T_(4~6)时罗哌卡因血药浓度差异无统计学意义(P>0.05),罗哌卡因药峰浓度降低(P<0.01),罗哌卡因血药浓度达峰时间和时间-血药浓度曲线下面积差异无统计学意义(P>0.05)。结论右美托咪定可降低兔坐骨神经阻滞时罗哌卡因的血药浓度。Objective To evaluate the effect of dexmedetomidine on the blood concentrations of ropivacaine during sciatic nerve block in rabbits.Methods Twelve New Zealand rabbits of both sexes,weighing 2-3 kg,were randomly divided into ropivacaine group(R group)and ropivacaine mixed with dexmedetomidine group(RD group).The right femoral vein was cannulated for blood sampling in both groups,0.375%ropivacaine 3 ml was injected around the left sciatic nerve in group R,and 0.375%ropivacaine 3 ml containing 1.5μg/kg dexmedetomidine was injected instead in group RD.Blood samples from the right femoral vein were collected before nerve block(T_(0))and at 15,30,45,60,120 and 180 min after nerve block(T_(1-6))for determination of plasma concentrations of ropivacaine using high-performance liquid chromatography after centrifugation,and concentration-time curves were plotted.Results Compared with group R,the blood concentrations of ropivacaine were significantly decreased at T_(1-3)(P<0.05),no significant change was found in the blood concentrations of ropivacaine at T_(4-6)(P>0.05),the peak blood concentration of ropivacaine was significantly decreased(P<0.01),and no significant change was found in the time to peak blood concentrations of ropivacaine or area under the concentration-time curves in group RD(P>0.05).Conclusions Dexmedetomidine can decrease the blood concentrations of ropivacaine during sciatic nerve block in rabbits.

关 键 词：右美托咪啶 坐骨神经 神经传导阻滞 酰胺类 血药浓度 

分 类 号：R965[医药卫生—药理学]