克拉玛依地区育龄期妇女抗缪勒管激素参考区间建立及与性激素相关性探讨  

Establishment of reference interval of anti-Mullerian hormones in women of childbearing age in Karamay area and its correlation with sex hormones

作　　者：王晓妹 罗超 刘雅琳 朱文秀 王福刚 宋兴勃[2] 何訸[2] WANG Xiaomei;LUO Chao;LIU Yalin;ZHU Wenxiu;WANG Fugang;SONG Xingbo;HE He(Department of Clinical Laboratory,Karamay Hospital of Integrated Traditional Chinese and Western Medicine(Karamay People's Hospital),Karamay,Xinjiang 834000,China;Department of Laboratory Medicine,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China)

机构地区：[1]新疆维吾尔自治区克拉玛依市中西医结合医院(人民医院)检验科,新疆克拉玛依834000 [2]四川大学华西医院实验医学科,四川成都610041

出　　处：《国际检验医学杂志》2022年第17期2156-2160,共5页International Journal of Laboratory Medicine

摘　　要：目的建立克拉玛依地区育龄期妇女血清抗缪勒管激素(AMH)参考区间。方法收集2018年3月至2021年10月克拉玛依市人民医院和克拉玛依市中心医院健康管理体检中心筛查AMH需求者1594例,纳入1498例符合标准者,用电化学发光法测定血清AMH水平;其中223例研究对象(月经第2~3天)同时检测血清雌二醇(E2)、孕酮(Prog)、泌乳素(PRL)、睾酮(Test)、促卵泡生成激素(FSH)、促黄体生成激素(LH)水平,选择第2.5百分位数(P_(2.5))和第97.5百分位数(P_(97.5))为AMH参考区间上下限。结果育龄期妇女AMH水平随年龄增加而递减;分别为:20~24岁1.16~10.95 ng/mL、>24~29岁1.03~10.53 ng/mL、>29~34岁0.49~7.98 ng/mL、>34~39岁0.25~6.41 ng/mL、>39~44岁0.12~4.91 ng/mL、>44~49岁0.01~2.23 ng/mL、>49岁<0.74 ng/mL。AMH与LH、Test在>24~29岁年龄段存在显著正相关(P<0.05);在>29~34岁年龄段,AMH与FSH呈显著负相关(P<0.05),与Test呈显著正相关(P<0.05);在>39~44岁年龄段AMH与FSH、LH均呈显著负相关(P<0.05);在>34~39岁和>44~49岁年龄段,AMH与六项性激素均无相关性。结论建立的育龄妇女AMH的参考区间能够满足临床需求,与性激素联合检测、分析,对育龄妇女相关疾病提供合理依据。Objective To establish the reference interval of serum anti-mullerian hormone(AMH)in women of childbearing age in Karamay area.Methods Totally 1594 women in need of AMH were screened in the Health Management Physical Examination Center of Karamay People's Hospital and Karamay Central Hospital from March 2018 to October 2021,and 1498 women meeting the criteria were included.Serum AMH level was determined by electrochemiluminescence.Serum levels of estradiol(E2),progesterone(Prog),prolac-tin(PRL),testosterone(Test),follicle-stimulating hormone(FSH)and luteinizing hormone(LH)were detec-ted in 223 women on the 2nd to 3rd day of menstruation.The 2.5th percentile(P_(2.5))and 97.5 percentile(P_(97.5))were selected as the upper and lower limits of the AMH reference intervals.Results The level of AMH de-creased with the increase of age.The level of AMH of 20-24 year-old women was 1.16-10.95 ng/mL,that of>24-29 year-old women was 1.03-10.53 ng/mL,that of>29-34 year-old women was 0.49-7.98 ng/mL,that of>34-39 year-old women was 0.25-6.41 ng/mL,that of>39-44 year-old women was 0.12-4.91 ng/mL,that of>44-49 year-old women was 0.01-2.23 ng/mL and>49 year-old women was<0.74 ng/mL.There were significant positive correlations between AMH and LH and Test in>24-29 year-old women(P<0.05).In>29-34 year-old women,AMH was significantly negatively correlated with FSH(P<0.05),and was significantly positively correlated with Test(P<0.05).There were significant negative corre-lations between AMH and FSH and LH in>39-44 year-old women(P<0.05).There was no correlation be-tween AMH and six sex hormones in>34-39 and>44-49 year-old women.Conclusion The established reference interval of AMH in women of childbearing age could meet the clinical needs,and provide a reasona-ble basis for the related diseases of women of childbearing age with the combined detection and analysis of sex hormones.

关 键 词：抗缪勒管激素 育龄妇女 参考区间 性激素 

分 类 号：R711.75[医药卫生—妇产科学]