南京地区糖尿病足与血清UA、Hcy、HbAlc和LDL-c水平相关性研究  

Correlation between severity of diabetic foot disease and serum UA,Hcy,HbAlc and LDL-c levels in Nanjing Area

作　　者：徐卫平[1] 张国英[1] 蔡峰[1] 潘曹敏[1] 李鑫[2] XYU Wei-ping;ZHANG Guo-ying;CAI Feng;PAN Cao-min;LI Xin(Department of Laboratory Medicine,Nanjing Hospital of Integrated Traditional Chinese and Western Medicine,Affiliated to Nanjing University of Traditional Chinese Medicine,Nanjing,Jiangsu 210014,China;Department of Science and Education,Nanjing Hospital of Integrated Traditional Chinese and Western Medicine,Affiliated to Nanjing University of Traditional Chinese Medicine,Nanjing,Jiangsu 210014,China)

机构地区：[1]南京中医药大学附属南京市中西医结合医院检验科,江苏南京210014 [2]南京中医药大学附属南京市中西医结合医院科教科,江苏南京210014

出　　处：《公共卫生与预防医学》2022年第5期69-72,共4页Journal of Public Health and Preventive Medicine

摘　　要：目的分析南京地区糖尿病足(DF)病情严重程度与血清UA、Hcy、HbAlc和LDL-c水平的相关性,为评估DF病情严重程度提供依据。方法研究对象选取2019年6月至2020年6月南京地区T2DM患者628例,根据患者是否伴有DF分为对照组(n=502,不合并DF)和观察组(n=126,合并DF),将DF患者根据Wagner分级法将糖尿病足分为6个级别(0~5级),其中为轻度(0~1级,n=68)、中度(2~3级,n=42)和重度(4~5级,n=18),对比不同病情严重程度组糖尿病足患者血清UA、Hcy、HbAlc和LDL-c水平,绘制ROC曲线分析Hcy、HbAlc和LDL-c在糖尿病足鉴别诊断中的效能,采用Spearman相关性分析糖尿病足病情严重程度与血清UA、Hcy、HbAlc和LDL-c水平的相关性;结果观察组血清UA、Hcy、HbAlc和LDL-c水平显著高于对照组(P<0.05);重度组血清UA、Hcy、HbAlc和LDL-c水平显著高于轻度组和中度组(P<0.05);中度组血清UA、Hcy、HbAlc和LDL-c水平显著高于轻度组(P<0.05);Spearman相关性分析显示DF病情严重程度与UA、Hcy、HbAlc和LDL-c均呈正相关(r=0.457,0.468,0.411,0.492,P<0.05);ROC曲线显示血清UA、Hcy、HbAlc和LDL-c联合检测预测DF患者病情严重程度的敏感度为95.65%,特异度为96.78%;结论南京地区DF患者血清UA、Hcy、HbAlc和LDL-C与病情严重程度显著相关,对DF患者监测病情进展情况具有重要临床价值。Objective To analyze the correlation between the severity of diabetic foot(DF)and the levels of serum UA,Hcy,HbAlc and LDL-c in Nanjing area,and to provide a basis for evaluating the severity of DF.Methods A total of 628 T2DM patients in Nanjing area from June 2019 to June 2020 were selected as subjects.According to whether patients had DF,they were divided into control group(n=502,without DF)and observation group(n=126,with DF).DF patients were divided into 6 grades(0-5)according to Wagner grading method.There were mild(0-1 grade,n=68),moderate(2-3 grade,n=42)and severe(4-5 grade,n=18).Serum UA,Hcy,HbAlc and LDL-c levels of diabetic foot patients in different severity groups were compared.ROC curve was drawn to analyze the efficacy of Hcy,HbAlc and LDL-C in the differential diagnosis of diabetic foot.Spearman correlation was used to analyze the correlation between the severity of diabetic foot and serum UA,Hcy,HbAlc and LDL-C levels.Results The serum levels of UA,Hcy,HbAlc and LDL-c in observation group were significantly higher than those in control group(P<0.05).The serum levels of UA,Hcy,HbAlc and LDL-C in severe group were significantly higher than those in mild and moderate groups(P<0.05).The serum levels of UA,Hcy,HbAlc and LDL-c in moderate group were significantly higher than those in mild group(P<0.05).Spearman correlation analysis showed that DF illness severity and UA,Hcy,HbAlc,and there was a positive correlation of LDL-c(r=0.457,0.468,0.511,0.492,P<0.05);ROC curve showed that the sensitivity and specificity of the combined detection of serum UA,Hcy,HbAlc and LDL-c in predicting the severity of DF patients were 95.65%and 96.78%respectively.Conclusion Serum UA,Hcy,HbAlc and LDL-C of DF patients in Nanjing were significantly correlated with the severity of the disease,which has important clinical value for monitoring the progress of DF patients.

关 键 词：糖尿病足 病情 血清UA、Hcy、HbAlc和LDL-c水平 

分 类 号：R181[医药卫生—流行病学]