HIV感染者疲劳发病率的Meta分析  

Meta-analysis of the incidence of fatigue among people living with HIV

作　　者：郁艳 翁文佳 王新宇 黄晓婕[2] 张明[1] 高艳青 YU Yan;WENG Wen-jia;WANG Xin-yu;HUANG Xiao-jie;ZHANG Ming;GAO Yan-qing(Department of Dermatology,Beijing Youan Hospital,Capital Medical University,100069,China)

机构地区：[1]首都医科大学附属北京佑安医院皮肤性病科,100069 [2]首都医科大学附属北京佑安医院感染科,100069 [3]国家皮肤与免疫疾病临床医学研究中心分中心建设单位,北京100069

出　　处：《传染病信息》2022年第4期325-330,共6页Infectious Disease Information

基　　金：“十三五”国家科技重大专项(2017ZX10201101);北京市优秀人才青年拔尖个人项目(2018000021223ZK04)。

摘　　要：目的 采用Meta分析评价1996—2021年HIV感染者疲劳发病率情况。方法 检索Pubmed、Embase、Cochrane library和PsycINFO数据库中有关HIV感染者疲劳发病率的观察性研究。使用Stata 16.0软件,计算疲劳合并发病率及其95%CI值,采用敏感性分析和亚组分析探索异质性来源。结果 最终纳入23篇文献,共包括8213例病例。Meta分析显示HIV感染者疲劳合并发病率为62%(95%CI:53%~70%);亚组分析结果显示HIV感染者年龄较小、总体联合抗反转录病毒疗法接受率低、有睡眠障碍和抑郁的群体疲劳发病率更高(P <0.05)。结论 HIV感染者疲劳发病率较高,应引起医务人员重视。Objective To do a meta-analysis of the incidence of fatigue among people living with HIV from 1996 to 2021.Methods Pub Med, Embase, Cochrane Library, and PsycINFO, were used for search studies on the incidence of fatigue in HIV-infected patients. The stata 16.0 software was used to calculate the fatigue combined prevalence and its 95%CI value, and sensitivity analysis and subgroup analysis were used to explore the source of heterogeneity. Results The research finally enrolled 23 documents, including 8213samples. Meta-analysis showed that the incidence of fatigue among people living with HIV was 62%(95%CI: 53% ~ 70%). Subgroup analysis showed that HIV patients with younger age, less use of combination antiretroviral therapy, sleep disorders, and depression had a higher incidence of fatigue(P <0.05). Conclusions The incidence of fatigue among people living with HIV is relatively high, which should be pay attention to by medical service providers.

关 键 词：HIV 疲劳 发病率 年龄 联合抗反转录病毒疗法 抑郁 睡眠障碍 META分析 

分 类 号：R512.91[医药卫生—内科学]