一种带吡啶悬臂大环异双核Zn(Ⅱ)-Ni(Ⅱ)配合物的合成、晶体结构及其DNA结合/切割性质  

Synthesis,Crystal Structure,and DNA Binding/Cleavage Properties of a Macrocyclic Heterobinuclear Zn(Ⅱ)-Ni(Ⅱ) Complex with Pyridylmethyl Pendant-Arms

作　　者：丁佩佩 李铭 吴宇 闫俊涛 王春蕾 王洋 毛佳伟 DING Pei‑Pei;LI Ming;WU Yu;YAN Jun‑Tao;WANG Chun‑Lei;WANG Yang;MAO Jia‑Wei(School of Chemical and Environmental Engineering,Wuhan Polytechnic University,Wuhan 430023,China;Institute of Product Quality Supervision and Inspection,Chengdu 610100,China)

机构地区：[1]武汉轻工大学化学与环境工程学院,武汉430023 [2]成都市产品质量监督检验所,成都610100

出　　处：《无机化学学报》2022年第9期1853-1861,共9页Chinese Journal of Inorganic Chemistry

基　　金：湖北省重点研发项目(No.2020BBB068);湖北省自然基金(No.2020CFB400)资助。

摘　　要：合成了一种带吡啶悬臂的不对称大环异双核金属Zn(Ⅱ)-Ni(ⅡI)配合物[ZnNi(L)](ClO_(4))_(2)·H_(2)O(H_(2)L=3,3’-((ethane-1,2-diylbis((pyridin-2-ylmethyl)azanediyl))bis(methyl ene))bis(2-hydroxy-5-methylbenzaldehyde)),通过红外光谱、电喷雾质谱、单晶X射线衍射对其结构进行了表征。结果表明Zn(Ⅱ)和Ni(Ⅱ)的配位环境分别为扭曲的三角锥和正四面体。利用紫外光谱、粘度实验和循环伏安法对该配合物与DNA的相互作用模式进行了研究,结果表明配合物与小牛胸腺DNA(CT-DNA)的结合方式为插入模式,其相应的结合常数K_(b)=1.05×10^(5) L·mol^(-1)。另外,该配合物对pBR322 DNA有一定的切割作用。A bis-pyridine pendant-armed macrocyclic heterobinuclear Zn(Ⅱ)-Ni(Ⅱ)complex[ZnNi(L)](ClO_(4))_(2)·H_(2) O(H_(2) L=3,3’-((ethane-1,2-diylbis((pyridin-2-ylmethyl)azanediyl))bis(methylene))bis(2-hydroxy-5-methylbenzaldehyde))has been obtained and characterized by spectroscopy,elemental analysis and single-crystal X-ray diffraction.The coordination environment of Zn(Ⅱ)and Ni(Ⅱ)can be described as approximately distorted triangular prism and square pyramid,respectively.The Zn—Ni distance bridged by two phenoxide groups is 0.30363(6)nm.The interaction between the complex and calf thymus DNA(CT-DNA)has been further confirmed by UV-Vis spectrophotometry,viscosity,and cyclic voltammetry study.The complex showed a good binding property to CT-DNA with a binding constant of 1.05×10^(5) L·mol^(-1).The DNA cleavage activity has also been investigated using agarose gel electrophoresis.CCDC:2045334.

关 键 词：悬臂大环配合物 晶体结构 配位环境 DNA结合 DNA切割 

分 类 号：O614.241[理学—无机化学] O614.813[理学—化学]