CeO_(2)纳米酶活性与抗菌性能研究进展  

Application Progress of Cerium Oxide Nanozyme Activities and Antibacterial Properties

作　　者：郭佳靖 高艳芳[1] 张欣[1] GUO Jia-jing;GAO Yan-fang;ZHANG Xin(College of Chemical Engineering,Inner Mongolia University of Technology,Hohhot 010051,China)

机构地区：[1]内蒙古工业大学化工学院,内蒙古呼和浩特010051

出　　处：《化学试剂》2022年第9期1249-1256,共8页Chemical Reagents

基　　金：内蒙古自治区联合基金项目(2021LHMS02002);内蒙古工业大学科学研究项目(BS2021019)。

摘　　要：近年来,细菌多重耐药性(Multidrug Resistance,MDR)现象日益严重,已威胁到人类健康。纳米材料的出现,为这一难题的解决带来希望。其中,二氧化铈纳米颗粒(Cerium Oxide Nanoparticles,CeO_(2)NPs)作为一种新型抗菌剂,具有生产成本低、结构稳定性高、催化活性可调、生物安全性高等优点,因而具有重要研究价值。根据Ce^(3+)与Ce^(4+)含量比值变化,CeO_(2)NPs可表现出不同纳米酶活性,进而可调节生物体内活性氧(Reactive Oxygen Species,ROS)自由基的水平,从而有效杀死细菌,破坏其细胞结构。综述了CeO_(2)NPs用于多种模式微生物的抗菌性能,阐述其抗菌机理,分析不同因素对其抗菌性能的影响,并对其在抗菌领域的应用前景进行展望,期望对抗菌剂的开发和应用提供更多参考。In recent years,bacterial multidrug resistance(MDR)has become increasingly serious,which has threatened human health.The emergence of nanomaterials brings hope for the solution of this difficult problem.Cerium oxide nanoparticles(CeO_(2)NPs)as a new antibacterial agent,has the advantages of low production cost,high structural stability and adjustable catalytic activity and thus shows substantial research value.CeO_(2)NPs show different enzyme activities according to the content of Ce^(3+) and Ce^(4+),which then could regulate the level of reactive oxygen species(ROS)free radicals,so as to effectively kill bacteria and destroy their cell structure.The reports on antibacterial performance of CeO_(2)NPs against various model bacteria were summarized,and its antibacterial mechanism was elaborated in detail.The effects of diversely influence factors on antibacterial properties were also discussed.Finally,the application prospect of this antibacterial material was put forward,wishing to provide more reference for the development and application of antibacterial agents.

关 键 词：二氧化铈纳米颗粒 抗菌机理 纳米酶活性 活性氧物种 耐药性 

分 类 号：O69[理学—化学]