喹诺酮类抗生素的分子印迹电化学传感检测  

Molecular Imprinting based Electrochemical Detection of Quinolones Antibiotics

作　　者：温宇浩 孙大妮 张悦 周娜[3] 刘惠涛[2] 李金花 庄旭明[2] WEN Yu-hao;SUN Da-ni;ZHANG Yue;ZHOU Na;LIU Hui-tao;LI Jin-hua;ZHUANG Xu-ming(School of Marine Science and Technology,Harbin Institute of Technology(Weihai),Weihai 264209,China;College of Chemistry and Chemical Engineering,Yantai University,Yantai 264005,China;Shandong Key Laboratory of Coastal Environmental Processes,CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation,Shandong Research Center for Coastal Environmental Engineering and Technology,Yantai Institute of Coastal Zone Research,Chinese Academy of Sciences,Yantai 264003,China)

机构地区：[1]哈尔滨工业大学(威海)海洋科学与技术学院,山东威海264209 [2]烟台大学化学化工学院,山东烟台264005 [3]中国科学院烟台海岸带研究所,山东省海岸带环境工程技术研究中心,中国科学院海岸带环境过程与生态修复重点实验室,山东省海岸带环境过程重点实验室,山东烟台264003

出　　处：《化学试剂》2022年第9期1334-1341,共8页Chemical Reagents

基　　金：国家自然科学基金资助项目(22176210,21876199);烟台市科技发展计划项目(2020MSGY077);山东省自然科学基金项目(ZR2020KC032);中国科学院仪器设备功能开发技术创新项目。

摘　　要：喹诺酮类(QNs)抗生素残留极大危害生物体和环境,其含量低、种类多、基质复杂,通常需要进行样品前处理结合色谱/质谱分析以实现灵敏检测。分子印迹聚合物(MIPs)是具有与模板分子在形状、大小及官能团完全匹配的特异性识别位点的高分子聚合物,能选择性识别和富集目标分析物并消除干扰。电化学传感器具有高灵敏度、高选择性、响应时间短等优点,将分子印迹技术应用其中,得到的分子印迹电化学传感器(MIEC)具备了二者的优点。综述了MIEC的构建原理,主要包括电流传感器和电位传感器。此外,重点介绍了MIEC在工业生产和实际生活中对QNs的检测,包括恩诺沙星、氧氟沙星等。最后,提出了MIEC在QNs快速检测中面临的挑战和发展前景。The residues of quinolones(QNs)antibiotics are extremely harmful to organisms and the environment.QNs are low in content and diverse in species,and present in complex matrices.Usually,sample pretreatment combined with chromatographic/mass spectrometry analysis is required to achieve sensitive detection.Molecularly imprinted polymers(MIPs)are high molecular polymers with specific recognition sites that exactly match template molecules in shape,size and functional groups,which can selectively recognize and enrich target analytes and eliminate interference.Electrochemical sensors have the advantages of high sensitivity and selectivity,and short response time.Molecularly imprinted electrochemical sensors(MIEC)obtained by applying molecular imprinting technology have the advantages of both MIPs and electrochemical sensors.We summarized the construction principles of MIEC,mainly including current sensors and potential sensors.The detection of QNs(enrofloxacin,ofloxacin,etc.)in industrial production and real life by MIEC was then highlighted.Finally,the challenges and development prospects of MIEC in rapid detection of QNs were discussed.

关 键 词：喹诺酮类抗生素 分子印迹聚合物 电化学传感器 构建原理 快速检测 

分 类 号：O657.1[理学—分析化学]