痛风石病人的临床特征及其危险因素分析  

CLINICAL FEATURES OF TOPHI PATIENTS AND RELATED RISK FACTORS

作　　者：范又琳 周诗喆 杨敏[1] 陈颖[1] FAN Youlin;ZHOU Shizhe;YANG Min;CHEN Ying(Department of Endocrinology and Metabolic Diseases,The Affiliated Hospital of Qingdao University,Qingdao 266003,China)

机构地区：[1]青岛大学附属医院内分泌与代谢病科,山东青岛266003

出　　处：《青岛大学学报（医学版）》2022年第4期553-558,共6页Journal of Qingdao University(Medical Sciences)

基　　金：国家自然科学基金青年科学基金项目(81600601)。

摘　　要：目的探讨痛风石病人的临床特征及其危险因素,为痛风石的早期防治提供临床依据。方法收集2016—2021年就诊于我院山东省痛风病临床医学中心的2290例痛风病人的临床资料,比较有痛风石组和无痛风石组病人的临床特征,并分析其危险因素。结果两组病人的年龄、收缩压、舒张压、肾小球滤过率(eGFR)、血肌酐、尿素氮、总胆固醇、空腹血糖、血尿酸和病程等比较,差异均有统计学意义(t=-13.146~7.489,Z=-13.146,P<0.05)。两组病人合并高血压、高糖血症及糖尿病、肾功能轻度及中/重度受损的构成比等比较,差异均有统计学意义( χ^(2)=4.760~59.478,P<0.05);两组合并肥胖、高胆固醇血症与高三酰甘油血症比较,差异均无统计学意义。Logistic回归分析显示,年龄、高血压、高糖血症及糖尿病、高尿酸血症、肾功能不全、病程长等是痛风石发生的危险因素(OR=1.272~2.865,95%CI=1.022~4.730,P<0.05)。结论痛风石病人有年龄更大、病程更长、eGFR更低,以及血压、血肌酐、尿素氮、总胆固醇、空腹血糖、血尿酸等更高的临床特点。年龄大、高血压、高糖血症及糖尿病、高尿酸血症、肾功能受损、病程长等是痛风石发生的危险因素。Objective To investigate the clinical features of tophi patients and related risk factors,and to provide a cli-nical basis for the early prevention and treatment of tophi.Methods Clinical data were collected from 2290 gout patients who attended Shandong Gout Clinical Medical Center of our hospital from 2016 to 2021.Clinical features were compared between the patients with tophi and those without tophi,and related risk factors were analyzed.Results There were significant differences between the two groups in age,systolic blood pressure,diastolic blood pressure,glomerular filtration rate(eGFR),serum creatinine,blood urea nitrogen,total cholesterol,fasting blood glucose,blood uric acid,and disease duration(t=-13.146 to 7.489,Z=-13.146,P<0.05).There were also significant differences between the two groups in the composition ratios of hypertension,hyperglycemia,diabetes,and mild and moderate/severe renal impairment( χ^(2)=4.760-59.478,P<0.05),while there were no significant differences in obesity,hypercholesterolemia,and hypertriglyceridemia between the two groups.The logistic regression analysis showed that age,hypertension,hyperglycemia/diabetes,hyperuricemia,renal insufficiency,and long course of disease were risk factors for tophi(OR=1.272-2.865,95%CI=1.022-4.730,P<0.05).Conclusion Tophi patients tend to have an older age,a longer course of disease,a lower eGFR,and higher levels of blood pressure,serum creatinine,blood urea nitrogen,total cholesterol,fasting blood glucose,and serum uric acid.Old age,hypertension,hyperglycemia/diabetes,hyperuricemia,renal impairment,and long course of disease are risk factors for tophi.

关 键 词：痛风 高尿酸血症 结晶 代谢综合征 危险因素 

分 类 号：R589.7[医药卫生—内分泌]