真实世界中莲必治注射液疑似致肾功能异常的影响因素研究  

Real World Study on the influencing factors of Suspected Abnormal Renal Function in Patients Treated with Lianbizhi Injection

作　　者：王丽丽[1] 刘建平[1] 马辉[1] Wang Lili;Liu Jianping;Ma Hui(Beijing Jingmei Group General Hospital,Beijing 102300,China)

机构地区：[1]北京京煤集团总医院,北京102300

出　　处：《首都食品与医药》2022年第16期15-17,共3页Capital Food Medicine

摘　　要：目的分析真实世界中莲必治注射液疑似致肾功能异常患者的临床特征,探索使用莲必治注射液后出现肾功能异常的危险因素。方法对京煤集团总医院2019年191例使用莲必治注射液的患者进行回顾性分析,根据应用莲必治注射液后肾功能是否出现异常变化分为用药后异常变化组和用药后无异常变化组,使用Logistic回归模型分析应用莲必治注射液引起肾功能异常的可疑因素。结果用药前肌酐异常,合并使用万古霉素、呋塞米、头孢噻肟钠舒巴坦钠可能是发生肾功能异常的影响因素(P<0.05)。结论在应用莲必治注射液前应检查患者的肌酐水平,且谨慎与万古霉素等影响肾功能的药物合用。Objective To analyze the clinical features of patients with abnormal renal function Suspicion were caused by Lianbizhi Injection in real world,and to explore the risk factors of abnormal renal funeticn after the use of Lianbizhi injection.Methods A retrospective study among the 191 cases who treated by Lianbizhi Injection in 2019,and the patients were divided into two groups according to whether the abnormal changes of renal funeticn after the application of Lianbizhi injection.Influencing factors were screened with Logistic regression analysis.Results It was found that the use of Lianbizhi injection combined with abnormal creatinine or the combination of vancomycin,fur osemide,cefotaxime/sulbactam were the influencing factors of the abnormal changes of renal function.The result was statistically significant(P<0.05).Conclusion The creatinine level of patients should be checked before the use of Lianbi injection,and it should be carefully combined with vancomycin and other drugs that affect renal function.

关 键 词：莲必治注射液 肾功能异常 影响因素 真实世界 

分 类 号：R969.3[医药卫生—药理学]