左氧氟沙星联合替硝唑治疗慢性盆腔炎的疗效研究  

Effect of levofloxacin combined with tinidazole on chronic pelvic inflammatory disease

作　　者：崔晓飞 余莎莎 王芊晨 Cui Xiaofei;Yu Shasha;Wang Qianchen(Outpatient Department,Xinjiang Armed Police Corps General Hospital,Urumqi 830000,China;Department of Gynecology,Bozhou People's Hospital,Bole 833400,Xinjiang,China;Department of Obstetrics and Gynecology,Xinjiang Armed Police Corps General Hospital,Urumqi 830000,China)

机构地区：[1]新疆武警兵团总队医院门诊部,新疆乌鲁木齐830000 [2]博州人民医院妇科,新疆博乐833400 [3]新疆武警兵团总队医院妇产科,新疆乌鲁木齐830000

出　　处：《实用妇科内分泌电子杂志》2022年第7期58-61,共4页Electronic Journal of Practical Gynecological Endocrinology

摘　　要：目的研究左氧氟沙星联合替硝唑治疗慢性盆腔炎的临床疗效。方法选取80例慢性盆腔炎患者,采用抽签法分为对照组及研究组,各40例。对照组给予替硝唑单药治疗,研究组给予左氧氟沙星联合替硝唑治疗。对比两组治疗效果、炎性因子水平及不良反应发生情况。结果研究组治疗总有效率为97.50%,明显高于对照组的80.00%,差异有统计学意义(P<0.05)。治疗后,两组C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)及白细胞介素(IL-8)水平均较治疗前明显下降,且研究组各项指标水平均低于对照组,差异有统计学意义(P<0.05)。研究组不良反应发生率明显低于对照组,差异有统计学意义(P<0.05)。结论左氧氟沙星联合替硝唑治疗慢性盆腔炎患者效果更理想,可有效降低患者各项炎性因子水平,且安全性较高,值得临床推广与应用。Objective To study the clinical efficacy of levofloxacin combined with tinidazole in the treatment of chronic pelvic inflammatory disease.Methods 80 patients with chronic pelvic inflammatory disease were selected and divided into control group and study group by lottery,with 40 cases in each group.The control group was treated with tinidazole alone,while the study group was treated with levofloxacin combined with tinidazole.The treatment effect,inflammatory factors and adverse reactions were compared between the two groups.Results The total effective rate of the study group was 97.50%,which was significantly higher than 80.00% of the control group,and the difiFerence was statistically significant(P<0.05).After treatment,the levels of C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)and interleukin-8(IL-8)in the two groups were significantly decreased compared with those before treatment,and the levels of all indexes in the study group were lower than those in the control group,and the difFerences were statistically significant(P<0.05).The incidence of adverse reactions in the study group was significantly lower than that in the control group,and the difference was statistically significant(PV0.05).Conclusion Levofloxacin combined with tinidazole is more effective in the treatment of patients with chronic pelvic inflammatory disease,which can effectively reduce the levels of inflammatory factors in patients with high safety,and is worthy of clinical promotion and application.

关 键 词：慢性盆腔炎 左氧氟沙星 替硝唑 炎性因子 

分 类 号：R711.33[医药卫生—妇产科学]