孟鲁司特钠咀嚼片治疗儿童慢性咳嗽的临床效果研究  

Study on clinical effect of montelukast sodium chewable tablets in the treatment of chronic cough in children

作　　者：张丽丽[1] 于静 ZHANG Li-li;YU Jing(Department of Pediatrics,Liaocheng People's Hospital Dongchangfu Hospital,Liaocheng 252000,China)

机构地区：[1]聊城市人民医院东昌府院区儿科,252000

出　　处：《中国现代药物应用》2022年第15期11-14,共4页Chinese Journal of Modern Drug Application

摘　　要：目的分析孟鲁司特钠咀嚼片治疗儿童慢性咳嗽的临床效果。方法80例慢性咳嗽患儿,采用电脑随机分组法分为对照组与观察组,每组40例。对照组患儿采用常规药物治疗,观察组患儿在对照组基础上加用孟鲁司特钠咀嚼片治疗。比较两组患儿的临床治疗效果、血清炎性因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-4(IL-4)、超敏C反应蛋白(hs-CRP)]水平、不良反应发生情况、临床症状消失时间及治疗前后咳嗽评分、尿白三烯水平。结果观察组患儿的临床治疗总有效率97.50%明显高于对照组的75.00%,差异具有统计学意义(P<0.05)。观察组患儿的TNF-α、IL-4、hs-CRP水平分别为(20.02±2.06)ng/L、(30.06±3.16)ng/L、(7.06±9.06)mg/L,均低于对照组的(29.83±4.16)ng/L、(39.66±5.18)ng/L、(13.25±9.18)mg/L,差异具有统计学意义(P<0.05)。治疗前,两组患儿的咳嗽评分对比差异无统计学意义(P>0.05);治疗后,两组患儿的咳嗽评分均低于本组治疗前,且观察组患儿的咳嗽评分(0.96±0.06)分低于对照组的(1.86±0.18)分,差异具有统计学意义(P<0.05)。两组患儿治疗过程中的不良反应发生率对比,差异无统计学意义(P>0.05)。观察组患儿的咳嗽、咳喘消失时间分别为(10.26±3.66)、(5.96±1.06)d,均明显短于对照组的(15.16±4.86)、(9.86±3.18)d,差异具有统计学意义(P<0.05)。治疗前,两组患儿的尿白三烯水平对比差异无统计学意义(P>0.05);治疗后,两组患儿的尿白三烯水平均低于本组治疗前,且观察组患儿的尿白三烯水平(40.96±6.06)μg/mmol Cr低于对照组的(60.86±7.18)μg/mmol Cr,差异具有统计学意义(P<0.05)。结论采取孟鲁司特钠咀嚼片治疗儿童慢性咳嗽具有较为理想的临床效果,可有效改善患儿临床相关症状,不良反应发生风险小,安全性高,对患儿的病情恢复具有积极促进作用,值得在临床中推广运用。Objective To analyze the clinical effect of montelukast sodium oral granules or chewable tablets in the treatment of chronic cough in children.Methods A total of 80 children with chronic cough were divided into control group and observation group by computer randomization method,with 40 cases in each group.Children in the control group were treated with conventional medicine,and children in the observation group were additionally treated with montelukast sodium chewable tablets on the basis of the control group.Both groups were compared in terms of clinical effect,serum inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-4(IL-4),high-sensitivity C-reactive protein(hs-CRP)]levels,occurrence of adverse reactions,disappearance time of clinical symptoms,cough score and urinary leukotriene level before and after treatment.Results The total effective rate of clinical treatment in the observation group was 97.50%,which was significantly higher than 75.00%in the control group,and the difference was statistically significant(P<0.05).The levels of TNF-α,IL-4 and hs-CRP in the observation group were(20.02±2.06)ng/L,(30.06±3.16)ng/L and(7.06±9.06)mg/L,which were lower than(29.83±4.16)ng/L,(39.66±5.18)ng/L,and(13.25±9.18)mg/L in the control group,and the differences were statistically significant(P<0.05).Before treatment,there was no statistically significant difference in cough scores between the two groups(P>0.05).After treatment,the cough scores of the two groups were lower than those of this group before treatment,and the cough score(0.96±0.06)points of the observation group was lower than(1.86±0.18)points of the control group.All the differences were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups during treatment(P>0.05).The disappearance time of cough and asthma in the observation group were(10.26±3.66)and(5.96±1.06)d,which were significantly shorter than(15.16±4.86)and(9.86±3.18)d in the control

关 键 词：孟鲁司特钠咀嚼片 儿童慢性咳嗽 临床效果 咳嗽评分 不良反应 

分 类 号：R725.6[医药卫生—儿科]