改良限盐DASH饮食配合氨氯地平对原发性高血压患者心血管功能的影响分析  

Effect analysis of modified salt-restricted DASH diet combined with amlodipine on cardiovascular function in patients with essential hypertension

作　　者：查佳 CHA Jia(Qingyuan Manchu Autonomous County People's Hospital,Fushun 113300,China)

机构地区：[1]清原满族自治县人民医院,113300

出　　处：《中国现代药物应用》2022年第15期183-185,共3页Chinese Journal of Modern Drug Application

摘　　要：目的探讨改良限盐终止高血压膳食疗法(DASH)饮食配合氨氯地平对原发性高血压患者心血管功能的影响。方法98例原发性高血压患者,按照随机数字表对照法分为观察组与对照组,每组49例。对照组实施苯磺酸氨氯地平片治疗,观察组在对照组基础上联合使用改良限盐DASH饮食治疗。对比两组干预前后的收缩压、舒张压、收缩压变异性、舒张压变异性、颈动脉内膜中层厚度(IMT)、左室质量指数及不良心血管事件发生情况。结果干预后,两组收缩压、舒张压、收缩压变异性、舒张压变异性均低于干预前,且观察组收缩压(116.33±8.12)mm Hg(1 mm Hg=0.133 kPa)、收缩压变异性(10.08±2.12)mm Hg、舒张压变异性(10.34±2.87)mm Hg低于对照组的(121.34±7.64)、(13.05±3.17)、(11.55±1.06)mm Hg,差异有统计学意义(P<0.05);两组干预后舒张压组间对比,差异无统计学意义(P>0.05)。干预后,两组IMT均低于干预前,且观察组IMT(1.01±0.14)mm低于对照组的(1.15±0.15)mm,差异有统计学意义(P<0.05);观察组左室质量指数与干预前比较,差异无统计学意义(P>0.05);对照组左室质量指数高于治疗前,且对照组左室质量指数(137.67±9.24)g/m^(2)高于观察组的(133.58±8.34)g/m^(2),差异有统计学意义(P<0.05)。观察组不良心血管事件发生率为2.04%,低于对照组的12.24%,差异有统计学意义(P<0.05)。结论改良限盐DASH饮食配合氨氯地平对原发性高血压患者心血管功能有积极的影响,可以改善患者的血压状况,减少不良心血管事件的发生,不影响患者的左室质量指数。Objective To discuss the effect of modified salt-restricted dietary approaches to stop hypertension(DASH)diet combined with amlodipine on cardiovascular function in patients with essential hypertension.Methods A total of 98 patients with essential hypertension were divided into observation group and control group according to the random numerical table,with 49 cases in each group.The control group was treated with amlodipine besylate tablets,and the observation group was treated with modified salt-restricted DASH diet on the basis of the control group.Both groups were compared in terms of systolic blood pressure,diastolic blood pressure,systolic blood pressure variability,diastolic blood pressure variability,carotid intima-media thickness(IMT),left ventricular mass index before and after intervention,and occurrence of adverse cardiovascular events.Results After intervention,the systolic blood pressure,diastolic blood pressure,systolic blood pressure variability,and diastolic blood pressure variability in the two groups were lower than those before intervention in this group;the systolic blood pressure(116.33±8.12)mm Hg(1 mm Hg=0.133 kPa)and systolic blood pressure variability(10.08±2.12)mm Hg and diastolic blood pressure variability(10.34±2.87)mm Hg in the observation group were lower than(121.34±7.64),(13.05±3.17)and(11.55±1.06)mm Hg in the control group;all the differences were statistically significant(P<0.05).After intervention,there was no statistically significant difference in diastolic blood pressure between the two groups(P>0.05).After intervention,the IMT of the two groups was lower than that of this group before intervention,and the the IMT(1.01±0.14)mm of the observation group was lower than(1.15±0.15)mm of the control group,and the difference was statistically significant(P<0.05).In the observation group,there was no statistically significant difference in left ventricular mass index before and after intervention(P>0.05).The left ventricular mass index in the control group was higher than tha

关 键 词：终止高血压膳食疗法 氨氯地平 原发性高血压 心血管功能 

分 类 号：R544.11[医药卫生—心血管疾病]