铁调素及维生素D水平与儿童缺铁性贫血的研究进展  

Research progress on the correlation between hepcidin and vitamin D levels in children with iron deficiency anemia

作　　者：王宇茹 邹静雯 王云[1] 袁博[1] 柏金秀[1] Wang Yuru;Zou Jingwen;Wang Yun;Yuan Bo;Bai Jinxiu(Department of Pediatrics,Affiliated Hospital of Hebei University,Hebei Province,Baoding 071000,China)

机构地区：[1]河北大学附属医院儿科,保定071000

出　　处：《新医学》2022年第9期625-629,共5页Journal of New Medicine

摘　　要：缺铁性贫血(IDA)是儿童时期常见的贫血类型,是由于各种原因引起机体铁缺乏,导致血红蛋白合成水平下降而引起的贫血,IDA会对儿童生长发育造成不良影响。铁调素对铁代谢起负性调控作用,近年的研究表明,铁调素可作为IDA早期诊断及疗效评估的指标之一。维生素D对铁调素有直接或间接的抑制作用,维生素D缺乏是儿童贫血的常见诱因之一,且其缺乏程度与贫血严重程度呈正相关,维生素D联合铁剂治疗对IDA有较好的防治作用。该文就目前关于铁调素及维生素D水平在儿童IDA中的相关性及两者在该病诊治中的意义进行介绍,以期为儿童IDA的临床管理提供新的诊治思路。Iron deficiency anemia(IDA)is a common type of anemia in childhood caused by iron deficiency due to varying causes,which can result in a decline in the synthesis of hemoglobin.IDA will adversely affect the growth and development of children.Hepcidin exerts a negative regulatory effect on iron metabolism.Recent studies have shown that hepcidin can be used as one of the biomarkers for early diagnosis of IDA and the response evaluation.Vitamin D exerts a direct or indirect inhibitory effect upon hepcidin.Lack of vitamin D is one of the common triggers for anemia in children,and the degree of vitamin D deficiency is positively correlated with the degree of anemia.Combined therapy of vitamin D and iron exerts preventive and therapeutic effect on IDA.In this article,the correlation between the hepcidin and vitamin D levels in IDA children and their significance in the diagnosis and treatment of IDA were reviewed,aiming to provide novel diagnostic and therapeutic ideas for the clinical management of pediatric IDA.

关 键 词：铁调素 维生素D 缺铁性贫血 儿童 相关性 诊断 治疗 

分 类 号：R725.5[医药卫生—儿科]