神经丝轻链蛋白在周围神经病中的应用价值探究  

Value of Neurofilament Light Chain as a Biomarker in Peripheral Neuropathy

作　　者：孙小玲 黄凯伟 万新贝 吴莹 李志军 SUN Xiaoling;HUANG Kaiwei;WAN Xinbei;WU Ying;LI Zhijun(Department of Internal Medicine,the Affiliated Hospital of Hubei Provincial Government,Wuhan 430071,China;Department of Neurology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China)

机构地区：[1]湖北省直属机关医院内科,湖北省武汉市430071 [2]华中科技大学同济医学院附属同济医院神经内科,湖北省武汉市430030

出　　处：《中国全科医学》2022年第32期3977-3983,共7页Chinese General Practice

基　　金：湖北省自然科学基金面上项目(2020CFB744);湖北省卫生健康委员会科研项目(WJ2021M119)。

摘　　要：神经丝轻链蛋白(NfL)已被确定为许多中枢神经系统疾病中轴突损伤的生物标志物,近年来关于NfL在周围神经病中的应用价值也逐渐引起关注。本研究回顾了血清NfL(sNfL)与各种免疫介导的周围神经病〔吉兰巴雷综合征(GBS)、慢性炎性脱髓鞘性神经根神经病(CIDP)等〕、遗传性周围神经病、药物相关性周围神经病、糖尿病周围神经病等轴突损伤的动态变化之间的关系,综合分析的结论为:sNfL定量可作为一个非常有潜力的生物标志物,监测疾病活动,评估疾病短期预后、长期预后,还可作为未来的临床试验和监测治疗反应的指标。Neurofilament light chain(NfL)has been identified as a biomarker of axonal injury in a variety of central nervous system diseases.The value of NfL as a biomarker in peripheral neuropathy has gained increasing attention.We reviewed the relationships of serum NfL with and the dynamics of axonal injury in various immune-mediated peripheral neuropathies(such as Guillain-Barre syndrome and chronic inflammatory demyelinating polyradiculoneuropathy),hereditary peripheral neuropathy,drug-induced peripheral neuropathies and diabetic peripheral neuropathy,and drew a conclusion after a comprehensive analysis:the quantified NfL may be used as a promising biomarker to monitor disease activity,assess short-and long-term prognosis,and also as a potential biomarker for clinical trials and monitoring treatment response.

关 键 词：周围神经系统疾病 神经微丝蛋白质类 神经丝轻链蛋白 标记物 临床 中枢神经系统 神经系统 

分 类 号：R341[医药卫生—基础医学]