桂枝茯苓胶囊治疗子宫内膜异位症及对患者血清Flk-1、COX-2、VEGF、PGE2水平的影响  

Effect of Guizhi fuling capsule for treating women with endometriosis and its influence on their expression levels of serum fetal liver kinase-1,cyclooxygenase-2,vascular endothelial growth factor,and prostaglandin 2

作　　者：李娜[1] 张永[1] LI Na;ZHANG Yong(The General Hospital of the Eastern Theater of the Chinese People's Liberation Army,Nanjing,Jiangsu Province,210000)

机构地区：[1]中国人民解放军东部战区总院,南京210000

出　　处：《中国计划生育学杂志》2022年第9期1977-1982,共6页Chinese Journal of Family Planning

摘　　要：目的:观察子宫内膜异位症(EMs)患者血清胎肝激酶-1(Flk-1)、环氧化酶-2(COX-2)血管内皮生长因子(VEGF)、前列腺素2(PGE_(2))表达及桂枝茯苓胶囊治疗效果。方法:选取2020年1月-2021年1月本院收治的EMs患者126例为EMs组,随机分为观察组与对照组各63例,均接受常规治疗,观察组加用桂枝茯苓胶囊,疗程3个月。健康体检女性40例为健康组。检测各组血清Flk-1、COX-2、VEGF、PGE_(2)水平,EMs组治疗后复查,评价EMs病灶面积、数字模拟量表(NRS)评分和中文版30项子宫内膜异位症健康量表(EHP-30)评分。结果:EMs组血清Flk-1(29.72±6.14 ng/ml)、COX-2(16.59±3.42 ng/ml)、VEGF(183.02±40.17 pg/ml)、PGE_(2)(589.74±56.33 pg/ml)水平高于健康组(9.02±1.13 ng/ml、5.45±1.38 ng/ml、58.52±14.37 pg/ml、105.63±14.59 pg/ml),且各上述指标r-AFSⅢ+Ⅳ期患者均高于Ⅰ+Ⅱ期患者并与r-AFS分期正相关(均P<0.05)。治疗后观察组病灶面积(5.08±1.33 cm^(2))、NRS(1.69±0.34分)及EHP-30(16.58±1.89分)评分均低于对照组(6.31±1.25 cm^(2)、3.01±0.59分、22.13±2.69分),血清Flk-1、COX-2、VEGF、PGE_(2)水平均低于对照组,总有效率(96.8%)高于对照组(85.7%),观察组Ⅲ+Ⅳ期患者疗效优于对照组Ⅲ+Ⅳ期患者(均P<0.05),不良反应未见明显增加。结论:Ems患者血清Flk-1、COX-2、VEGF、PGE_(2)水平异常高表达,且与临床分期相关;加用桂枝茯苓胶囊治疗可能通过下调Flk-1、COX-2、VEGF、PGE_(2)而发挥作用。Objective:To observe the expression levels of of serum fetal liver kinase-1(Flk-1),cyclooxygenase-2(COX-2),vascular endothelial growth factor(VEGF),and prostaglandin 2(PGE_(2))of women with endometriosis(EMs),and to study the effect of Guizhi fuling capsule for treating these patients.Methods:126 women with EMs were selected and were randomly divided in group A and group B from January 2020 to January 2021.63 women in group A had received conventional treatment for 3 months,and 63 women in group B had received conventional treatment combined with Guizhi fuling capsules for 3 months.Another 40 women who received healthy physical examination were selected in group C during the same period.The levels of serum Flk-1,COX-2,VEGF,and PGE_(2) of the women in the three groups were detected.The women in group A and B were given reexamination after treatment for evaluating their lesion area of Ems.Numerical rating scale(NRS)score and Chinese 30 version of Endometriosis Health Profile-30(EHP-30)score were conducted in group A and B.Results:The serum levels of FLK-1(29.72±6.14 ng/ml),COX-2(16.59±3.42 ng/ml),VEGF(183.02±40.17 pg/ml),and PGE2(589.74±56.33 pg/ml)of the women in group A and group B were significantly higher than those(9.02±1.13 ng/ml,5.45±1.38 ng/ml,58.52±14.37 pg/ml,and 105.63±14.59 pg/ml)of the women in group C,and which of the women with r-AFSⅢ-Ⅳstage of EMs were significantly higher than those of the women with r-AFSⅠ-Ⅱstage of EMs,and which were positively correlated with the r-AFS stage(all P<0.05).After treatment,the lesion area(5.08±1.33 cm^(2)),NRS score(1.69±0.34 points),and EHP-30 score(16.58±1.89 points)of the women in group A were significantly lower than those(6.31±1.25 cm^(2),3.01±0.59 points,and 22.13±2.69 points)of the women in group B.The serum levels of FLK-1,COX-2,VEGF,and PGE_(2) of the women in group A were significantly lower than those of the women in group B.The total effective rate(96.8%)of the women in group A was significantly higher than that(85.7%)of the women i

关 键 词：子宫内膜异位症 不同临床分期 桂枝茯苓胶囊 胎肝激酶-1 环氧化酶-2 血管内皮生长因子 前列腺素2 疼痛 病灶面积 

分 类 号：R271.9[医药卫生—中西医结合]