子宫内膜异位症伴不孕症CXCR5+CD4+T细胞表达与患者发病及自身抗体的相关性  

Correlation between the expression of CXCR5+CD4+T cells of infertility patients with endometriosis and their pathogenesis and autoantibodies

作　　者：张玉瑾 张文晶 王静[1] 吴楠 ZHANG Yujin;ZHANG Wenjing;WANG Jing;WU Nan(The Seventh Medical Center,PLA General Hospital,Beijing,100007)

机构地区：[1]解放军总医院第七医学中心,北京100007

出　　处：《中国计划生育学杂志》2022年第9期2068-2071,共4页Chinese Journal of Family Planning

基　　金：吴阶平医学基金项目(320.6750.17303)。

摘　　要：目的:分析子宫内膜异位症(EMS)伴不孕症CXCR5+CD4+T细胞的表达及与患者发病及自身抗体的相关性。方法:选择2019年1月-2021年2月本中心妇产/医学部收治的EMS合并不孕症患者78例作为观察组,单纯EMS患者50例作为对照组,均检测患者体内抗子宫内膜抗体(EMAb)、抗卵巢抗体(AoAb)、抗精子抗体(AsAb)、甲状腺自身抗体(ATA)、抗人绒毛膜促性腺激素(AhCGAb)、抗-β-2糖蛋白1抗体(α-β-2GP1)、CXCR5+CD4+T细胞水平,并分析各指标相关性。结果:观察组AsAb(3.32±0.54)、AoAb(2.94±0.28)、EMAb(3.21±0.62)、AhCGAb(3.64±0.59)、α-β-2GP1(3.28±0.61)和ATA(2.81±0.23)水平均高于对照组(1.43±0.39、2.13±0.34、1.32±0.43、2.03±0.48、1.29±0.57、2.01±0.21),CXCR5+CD4+T细胞水平(23.19±5.91)%高于对照组(9.34±2.88)%(均P<0.05);CXCR5+CD4+T细胞与EMS不孕症发病呈正相关,观察组AoAb、AsAb、EMAb、ATA、α-β-2GP1和AhCGAb与CXCR5+CD4+T细胞均呈正相关(均P<0.05)。结论:EMS伴不孕症患者CXCR5+CD4+T细胞及相关抗体表达均异常升高,且CXCR5+CD4+T细胞与EMS伴不孕症发病及自身抗体水平均呈正相关关系。Objective:To analyze the correlation between the expression of CXCR5+CD4+T cells of infertility patients with endometriosis(EMS)and their pathogenesis and autoantibodies.Methods:78 patients with EMS and infertility were selected in observation group,and 50 patients with EMS only were selected in control group from January 2019 to February 2021.The levels of endometrial antibody(EMAb),anti-ovarian antibody(AoAb),anti-sperm antibody(AsAb),thyroid autoantibody(ATA),anti-human chorionic gonadotropin antibody(AhCGAb),anti-β-2 glycoprotein 1(α-β-2GP1),and CXCR5+CD4+T cell of the patients in the two groups were detected,and the correlation of which was analyzed.Results:The levels of AsAb(3.32±0.54),AoAb(2.94±0.28),EMAb(3.21±0.62),AhCGAb(3.64±0.59),α-β-2GP1(3.28±0.61),and ATA(2.81±0.23)of the patients in the observation group were significantly higher than those(1.43±0.39,2.13±0.34,1.32±0.43,2.03±0.48,1.29±0.57,and 2.01±0.21)of the patients in the control group,and the CXCR5+CD4+T cell level(23.19±5.91%)of the patients in the observation group was significantly higher than that(9.34±2.88%)of the patients in the control group(all P<0.05).The level of CXCR5+CD4+T cells of the patients with EMS was positively correlated with their incidence of infertility.The levels of AoAb,AsAb,EMAb,ATA,α-β-2GP1,and AhCGAb of the patients in the observation group were positively correlated with their CXCR5+CD4+T cells level(all P<0.05).Conclusion:The CXCR5+CD4+T cells level and the related antibody level of the patients with EMS and infertility all increase abnormally,and there is a positive correlation between the expression of CXCR5+CD4+T cells level of the infertility patients with EMS and their autoantibody level.

关 键 词：子宫内膜异位症 不孕症 CXCR5+CD4+T细胞 自身抗体 相关性 

分 类 号：R711.71[医药卫生—妇产科学] R711.6[医药卫生—临床医学]