外周血PLAC1、TFPI预测重度子痫前期价值  

Value of the levels of peripheral blood placenta specific protein 1 and tissue factor pathway inhibitor of pregnant women for predicting their severe preeclampsia

作　　者：金雅芳 李小丹[1] JIN Yafang;LI Xiaodan(Wuxi Maternal and Child Health Care Hospital,Wuxi,Jiangsu Province,214000)

机构地区：[1]江苏省无锡市妇幼保健院,214000

出　　处：《中国计划生育学杂志》2022年第9期2141-2144,共4页Chinese Journal of Family Planning

摘　　要：目的:探究孕妇外周血胎盘特异性蛋白(PLAC1)和组织途径抑制物(TFPI)表达及预测重度子痫前期价值。方法:选取2018年6月-2020年12月本院收治的子痫前期患者101例作为观察组,其中重度子痫前期24例,正常妊娠孕妇100例作为对照组,检测外周血PLAC1和TFPI水平。结果:观察组外周血PLAC1水平(3.35±0.74ng/ml)低于对照组(4.12±1.29ng/ml),TFPI水平(47.29±7.16ng/ml)高于对照组(35.37±5.82ng/ml),且重度子痫前期孕妇外周血PLAC1水平(2.87±0.52ng/mL)子痫前期孕妇(3.50±0.79ng/mL),TFPI水平(52.94±8.56ng/ml)高于子痫前期孕妇(45.53±6.32ng/ml)(均P<0.05);受试者工作特征曲线分析,血PLAC1、TFPI联合预测重度子痫前期的曲线下面积为0.840,敏感度为83.3%,特异度为71.4%,预测效能高于单一指标检测(P<0.05)。结论:重度子痫前期患者外周血PLAC1水平降低、TFPI水平升高,二者联合检测有一定临床指导价值。Objective:To explore the value of the expression levels of peripheral blood placenta specific protein 1(PLAC1)and tissue factor pathway inhibitor(TFPI)of pregnant women for predicting their severe preeclampsia.Methods:A total of 101 pregnant women with preeclampsia were enrolled in observation group between June 2018 and December 2020,which included 24 cases with severe preeclampsia.100 normal pregnant women were enrolled in control group during the same period.The levels of PLAC1 and TFPI in peripheral blood of the women in the two groups were detected.Results:The PLAC1 level in peripheral blood(3.35±0.74ng/ml)of the women in the observation group was significantly lower than that(4.12±1.29ng/ml)of the women in the control group.The level of TFPI(47.29±7.16ng/ml)of the women in the observation group was significantly higher than that(35.37±5.82ng/ml)of the women in the control group.The PLAC1 level in peripheral blood(2.87±0.52 ng/ml)of the women with severe preeclampsia was significantly lower than that(3.50±0.79 ng/ml)of the women with preeclampsia,and the level of TFPI(52.94±8.56ng/ml)of the women with severe preeclampsia was significantly higher than that(45.53±6.32ng/ml)of the women with preeclampsia(all P<0.05).Receiver operating characteristic curve analysis showed that the area under the curve,the sensitivity,and the specificity of the combined the PLAC1 and TFPI levels for predicting severe preeclampsia were 0.840,83.3%,and 71.4%,respectively,and the predictive efficiency of which was significantly higher than that of the PLAC1 level of TFPI level alone(P<0.05).Conclusion:The level of PLAC1 in peripheral blood of the pregnant women with severe preeclampsia decreases,while their TFPI level increases.The combined detection of the PLAC1 and TFPI levels for predicting severe preeclampsia has certain guidance value in clinic.

关 键 词：重度子痫前期 胎盘特异性蛋白 组织途径抑制物 预测价值 

分 类 号：R714.244[医药卫生—妇产科学]