子宫内膜异位症患者血清VEGF、IGF-Ⅰ、MCP-1、MMP-9/TIMP-1表达及其相关性  

Expression and correlation of serum vascular endothelial growth factor,insulin-like growth factor-1,monocyte chemoattractant protein 1,and metalloproteinase-9/matrix metalloproteinase inhibitor-1 of women with endometriosis

作　　者：唐志坚[1] 杨欣[1] 李慧玲 苏会娜 王朝华[1] TANG Zhijian;YANG Xin;LI Huiling;SU Huina;WANG Chaohua(People's Hospital of Peking University,Beijing,100044)

机构地区：[1]北京大学人民医院,100044

出　　处：《中国计划生育学杂志》2022年第9期2159-2162,共4页Chinese Journal of Family Planning

基　　金：国家科技支撑计划项目(2015BAI13B04)。

摘　　要：目的:探讨子宫内膜异位症(EMs)患者血清血管内皮生长因子(VEGF)、胰岛素样生长因子-1(IGF-1)、单核细胞趋化蛋白1(MCP-1)及基质金属蛋白酶-9(MMP-9)/基质金属蛋白酶抑制剂-1(TIMP-1)的表达及其临床意义。方法:选取2020年1月-2021年12月本院收治的EMs患者124例纳入EMs组,健康体检女性124例纳入对照组,比较EMs组与对照组、不同EMs分期及伴不孕患者血清VEGF、IGF-Ⅰ、MCP-1、MMP-9/TIMP-1水平并分析EMs患者各指标水平相关性。结果:EMs组血清VEGF(252.45±51.49ng/L)、IGF-Ⅰ(142.89±30.11ng/ml)、MCP-1(30.74±4.21 ng/ml)、MMP-9/TIMP-1(2.07±0.32)均高于对照组(143.32±31.18 ng/L、52.23±16.44 ng/ml、8.44±1.45 ng/ml、0.55±0.14),且随着r-AFS分期的升高而增高,EMs组中伴不孕症者水平高于非不孕症者(均P<0.05)。相关性分析显示,Ems患者血清VEGF、IGF-Ⅰ、MCP-1、MMP-9/TIMP-1水平与r-AFS分期呈正相关性,各指标间呈两两正相关性(均P<0.05)。结论:EMs患者血清VEGF、IGF-Ⅰ、MCP-1、MMP-9/TIMP-1异常高表达,且与病情严重程度及不孕症相关。Objective:To investigate the expressions of serum vascular endothelial growth factor(VEGF),insulin-like growth factor-1(IGF-1),monocyte chemoattractant protein 1(MCP-1),and metalloproteinase-9(MMP-9)/matrix metalloproteinase inhibitor-1(TIMP-1)of women with endometriosis(EMs),and to study their clinical significance.Methods:A total of 124 women with EMs were selected in study group and 124 women who received healthy physical examinations were selected in control group from January 2020 to December 2021.The levels of serum VEGF,IGF-Ⅰ,MCP-1,and MMP-9/TIMP-1 of the women were compared between the two groups,among the women with different stage of EMs,and between the women with and without infertile.And the correlation of the levels of serum VEGF,IGF-Ⅰ,MCP-1,and MMP-9/TIMP-1 of the women was analyzed.Results:The levels of serum VEGF(252.45±51.49 ng/L),IGF-Ⅰ(142.89±30.11 ng/ml),MCP-1(30.74±4.21 ng/ml),and MMP-9/TIMP-1(2.07±0.32)of the women in the study group were significantly higher than those(143.32±31.18 ng/L,52.23±16.44 ng/ml,8.44±1.45 ng/ml,and 0.55±0.14)of the women in the control group,and which of the women in the study group had increased with the increase of r-AFS stage of EMs of the women.The levels of VEGF,IGF-Ⅰ,MCP-1,and MMP-9/TIMP-1 of the women with infertility in the study group were significantly higher than those of the women without infertility(all P<0.05).Correlation analysis showed that the levels of serum VEGF,IGF-Ⅰ,MCP-1,and MMP-9/TIMP-1 of the women were positively correlation with their r-AFS stage of EMs,and the VEGF level,IGF-Ⅰlevel,MCP-1 level,and MMP-9/TIMP-1 of the women with Ems had positive correlation each other(P<0.05).Conclusion:The expression levels of serum VEGF,IGF-Ⅰ,MCP-1,and MMP-9/TIMP-1 of the women with EMs are abnormal high,and which are related to the severity of EMs and the infertility of the women.

关 键 词：子宫内膜异位症 血管内皮生长因子 胰岛素样生长因子-1 单核细胞趋化蛋白 1 基质金属蛋白酶-9 基质金属蛋白酶抑制剂-1 相关性 

分 类 号：R711.71[医药卫生—妇产科学]