神经梅毒实验室检测研究进展  

Research progress on laboratory detection of neurosyphilis

作　　者：魏垠昊 石明巧 滕丽 陶传敏[1] WEI Yinhao;SHI Mingqiao;TENG Li;TAO Chuanmin(Department of Laboratory Medicine,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,P.R.China;Department of Laboratory Medicine,Shenzhen Maternity&Child Healthcare Hosptial,Shenzhen,Guangdong 518028,P.R.China;Department of Public Health Management,the Second People's Hospital of Karamay,Karamay,Xinjiang 834000,P.R.China)

机构地区：[1]四川大学华西医院实验医学科,成都610041 [2]深圳市妇幼保健院检验科,广东深圳518028 [3]克拉玛依市第二人民医院公共卫生管理科,新疆克拉玛依83400

出　　处：《华西医学》2022年第8期1243-1247,共5页West China Medical Journal

摘　　要：神经梅毒是梅毒螺旋体侵犯神经系统出现脑膜、血管、脑实质或脊髓等损害的一组临床综合征。目前并没有高度特异且灵敏的方法用于神经梅毒的诊断,其诊断主要依赖于临床表现、脑脊液异常以及临床医生的综合判断。目前的研究表明部分细胞因子和趋化因子有望用于神经梅毒的实验室检测。该文从神经梅毒的传统实验室检测、聚合酶链反应检测、细胞因子和趋化因子检测、现有诊断标准等方面,综述神经梅毒的研究进展,以期为临床检测和后续研究提供参考。Neurosyphilis is a group of clinical syndromes in which Treponema pallidum invades the nervous system and causes damage to the meninges,blood vessels,brain parenchyma or spinal cord.At present,there is no highly specific and sensitive method for the diagnosis of neurosyphilis,and its diagnosis mainly depends on clinical manifestations,abnormal cerebrospinal fluid and the comprehensive judgment of clinicians.Current studies show that some cytokines and chemokines are promising for laboratory detection of neurosyphilis.This article reviews the research progress of neurosyphilis from the aspects of traditional laboratory testing,polymerase chain reaction testing,cytokine and chemokine testing,and existing diagnostic criteria for neurosyphilis,in order to provide a reference for clinical testing and follow-up research.

关 键 词：神经梅毒 实验室检测 血清学试验 趋化因子CXC配体13 

分 类 号：R759.1[医药卫生—皮肤病学与性病学]