镇江市吸毒人群的HCV新发感染情况  

A prospective cohort study of HCV incidence among drug users in Zhenjiang City

作　　者：刘晓霞[1] 叶鲁 胡成锋 刘超[1] 李欣琰 唐军花 吴芬香 豆月 张明辉[1] LIU Xiaoxia;YE Lu;HU Chengfeng;LIU Chao;LI Xinyan;TANG Junhua;WU Fenxiang;DOU Yue;ZHANG Minghui(Zhenjiang Center for Disease Control and Prevention,Zhenjiang 212002,China;Department of HIV/STDs Prevention and Control,Jingkou District Center for Disease Control and Prevention,Zhenjiang 212013;Department of HIV/STDs Prevention and Control Dantu District Center for Disease Control and Prevention,Zhenjiang 212028)

机构地区：[1]镇江市疾病预防控制中心,江苏镇江212002 [2]京口区疾病预防控制中心,江苏镇江212013 [3]丹徒区疾病预防控制中心,江苏镇江212028

出　　处：《中国艾滋病性病》2022年第8期925-928,共4页Chinese Journal of Aids & STD

摘　　要：目的分析镇江市近年来HCV在吸毒人群中的新发感染情况及相关危险因素,为镇江市丙型肝炎疫情防控提供依据。方法自2019年1月至2021年12月,于当地派出所、强制戒毒所招募吸毒人员。同时采集5 mL静脉血进行HCV抗体检测,在HCV抗体阴性吸毒高危人群中选择观察对象,建立前瞻性研究队列。随访频率为每3个月一次,共持续3年。结果544名随访对象的总观察时间为1420人年,新发HCV感染者33名,总发病密度为2.32/100人年。多因素Cox比例风险回归分析显示一年内有过临时性伴(HR=2.7,P=0.006)、一年内有同时与多人发生性行为(HR=2.5,P=0.009)是新发HCV感染的危险因素,教育程度高中及以上(相对于初中及以下,HR=0.34,P=0.002)是新发HCV感染的保护因素。结论教育程度为初中及以下、有临时性伴、多性伴行为的吸毒人群为HCV新发感染高危人群,应针对该重点人群加强HCV防治知识宣传以及吸毒行为干预措施。Objective To analyze the incidence density and risk factors of hepatitis C virus(HCV)among drug users in Zhenjiang City,aiming to provide evidence to HCV control and prevention strategy development.Methods We conducted a prospective cohort study to recruit drug users from police stations and drug rehabilitation centers in Zhenjiang in 2019.Blood samples were collected to test for HCV anti-body.Drug users who were with HCV-negative were included in the study cohort.Follow up was conducted every three months for three years.Results We observed 33 HCV infection cases through 544 respondents over 1420 person-year,indicating the HCV incidence density among our study drug users was 2.32 per 100 person-year.Multivariate Cox regression showed that having temporary sexual partner within one year(HR=2.7,P=0.006),and having multiple sexual partners(HR=2.5,P=0.009)were risk factors to HCV infection.Having an education level of high school and higher(HR=0.34,P=0.002),compared to middle school or lower,was a protective factor to HCV infection.Conclusions Drug users are the high risk population to HCV infection.Advocacy and interventions should be conducted among drug users regarding the risk factors and drug addiction behavior.

关 键 词：丙型肝炎病毒新发感染 前瞻性队列研究 吸毒行为 行为学因素 

分 类 号：R512.6[医药卫生—内科学]