PROX1对早期非小细胞肺癌微创切除术后复发的预测意义  

Predictive value of PROX1 for recurrence after minimally invasive resection of early non-small cell lung cancer

作　　者：魏东[1] 辛运超 刘博[3] 容宇[1] 李彦明[1] 郝雁冰[1] Wei Dong;Xin Yunchao;Liu Bo;Rong Yu;Li Yanming;Hao Yanbing(Thoracic Surgery Department of First Affiliated Hospital of Hebei North University,Zhangjiakou 075000,China;Otorhinolaryngology Head and Neck Surgery Department of First Affiliated Hospital of Hebei North University,Zhangjiakou 075000,China;Pathology Department of First Affiliated Hospital of Hebei North University,Zhangjiakou 075000,China)

机构地区：[1]河北北方学院附属第一医院胸外科,张家口075000 [2]河北北方学院附属第一医院耳鼻咽喉头颈外科,张家口075000 [3]河北北方学院附属第一医院病理科,张家口075000

出　　处：《中华肺部疾病杂志（电子版）》2022年第4期494-497,共4页Chinese Journal of Lung Diseases(Electronic Edition)

基　　金：河北省卫建委重点科技研究计划(20200552)。

摘　　要：目的分析Prospero相关同源异形盒蛋白1(PROX1)对早期非小细胞肺癌(NSCLC)微创切除术后复发的预测意义。方法选择2019年12月至2021年12月我院收治的54例拟接受微创切除术的NSCLC患者,采用免疫组织化学染色法检测患者NSCLC癌组织和对应癌旁组织中PROX1表达情况。统计NSCLC复发情况,比较复发者与未复发者临床资料,采用Logistic多因素回归分析影响NSCLC患者术后复发的因素,采用受试者工作特征曲线(ROC)分析NSCLC癌组织中PROX1表达水平预测术后复发。结果癌组织中PROX1表达水平比癌旁组织高(P<0.05),癌组织中PROX1高表达例数比癌旁组织高(P<0.05);13例患者复发(24.07%)。复发患者淋巴结转移、PROX1高表达、TNM分期为Ⅱ期例数比未复发患者高(P<0.05);Logistic多因素回归分析显示PROX1高表达、淋巴结转移、TNM分期为Ⅱ期是NSCLC术后复发危险因素(P<0.05);ROC分析显示,癌组织中PROX1表达水平预测NSCLC术后复发的最佳截点为8.36,灵敏度为84.78%,特异度为89.13%。结论NSCLC癌组织PROX1高表达,PROX1蛋白表达是NSCLC术后复发的危险因素,为预测NSCLC术后复发的指标。Objective To investigate the predictive value of Prospero related homeobox protein 1(PROX1)in the recurrence of early non-small cell lung cancer(NSCLC)after minimally invasive resection.Methods 54 patients with NSCLC who were admitted to the hospital from June 2016 to December 2018 to undergo minimally invasive resection were selected as the research objects.The expression of PROX1 in NSCLC tissues and corresponding adjacent tissues was detected by immunohistochemical staining.The recurrence of NSCLC patients was counted,and the clinical characteristics of relapsed patients and non relapsed patients were compared.The factors affecting postoperative recurrence of NSCLC patients were analyzed by logistic regression analysis.The PROX1 expression level in NSCLC cancer tissue was analyzed by receiver operating characteristic curve(ROC)to predict the efficacy of postoperative recurrence.Results the expression level of PROX1 in cancer tissues was higher than that in adjacent tissues(P<0.05),and the number of cases with high expression of PROX1 in cancer tissues was higher than that in adjacent tissues(P<0.05),24 patients relapsed,and the recurrence rate was 25.53%(24/54).The number of cases with lymph node metastasis,high expression of PROX1 and TNM stageⅡin the recurrent group was higher than that in the non recurrent group(P<0.05),Logistic regression analysis showed that high expression of PROX1,lymph node metastasis and TNM stageⅡwere independent risk factors for postoperative recurrence of NSCLC(P<0.05),ROC analysis showed that the best cutoff point for predicting postoperative recurrence of NSCLC patients by PROX1 expression level in cancer tissues was 8.36,the sensitivity was 84.78%,the specificity was 89.13%,and the area under the curve(AUC)was 0.930(P<0.05).Conclusion the expression of PROX1 in cancer tissues of NSCLC patients is high,and the expression level of PROX1 protein is an independent risk factor for postoperative recurrence of NSCLC patients,which can be used as a sensitive index to predict postope

关 键 词：Prospero相关同源异形盒蛋白1 非小细胞肺癌 微创切除术 

分 类 号：R563[医药卫生—呼吸系统] R734.2[医药卫生—内科学]