杭白菊化学成分的研究  

Study on Chemical constituents from Chrysanthemum morifolium Ramat.

作　　者：孙立仁[1] 钟爱娇 徐兰兰 车仙花 李宁[3] 李雪征 姜哲[1,2] SUN Li-ren;ZHONG Ai-jiao;XU Lan-lan;CHE Xian-hua;LI Ning;LI Xue-zheng;JIANG Zhe(Yanbian University Hospital,Yanji Jilin,133000,China;College of Pharmacy,Yanbian University,Yanji Jilin 133002,China;College of Pharmacy,Shenyang Pharmaceutical University,Shenyang Liaoning 110016,China;Wantong Pharmacy Group Corporation,Tonghua Jilin 134000,China)

机构地区：[1]延边大学附属医院,吉林延吉133000 [2]延边大学药学院,吉林延吉133002 [3]沈阳药科大学中药学院,辽宁沈阳110016 [4]通化万通药业股份有限公司,吉林通化134001

出　　处：《时珍国医国药》2022年第7期1620-1622,共3页Lishizhen Medicine and Materia Medica Research

基　　金：吉林省科技发展计划基金(20190701034GH,20200201034JC);延边大学应用基础项目(延大科合字(2019)34号)。

摘　　要：目的 对菊科植物杭白菊中的化学成分进行分离和结构鉴定,为该植物资源开发利用提供依据。方法 采用硅胶柱色谱、ODS柱色谱、制备液相色谱等分离方法对杭白菊乙醇提取物进行分离纯化,根据理化性质以及氢谱(^(1)H-NMR)和碳谱(^(13)C-NMR)数据鉴定化合物结构。结果 从杭白菊中分离并鉴定出12个化合物,分别为:5,3’,4’-trihydroxyl-3,6,7-trimethyl flavones (1)、槲皮素(2)、洋艾素(3)、木犀草素(4)、芹菜素(5)、染料木苷(6)、芹菜素-7-O-β-D-芸香苷(7)、橙皮素-7-O-β-D-葡萄糖醛酸苷(8)、圣草酚-7-O-β-D-葡萄糖苷(9)、芹菜素-7-O-β-D-葡萄糖苷(10)、咖啡酸甲酯(11)、水杨酸(12)。结论 最后得出化合物1、6从该属中首次分离得到,化合物7、8、9从该植物中首次分离得到。Objective To study the chemical constituents from Chrysanthemum morifolium Ramat.and determine their chemical structures to provide a basis for the development and utilization of the plant resources.Methods The constituents from the ethanol extract of the flower of C.morifolium were separated and purified by normal silica gel,reversed-phase silica gel column chromatography and preparation HPLC.The structures of the compounds were identified according to physicochemical properties,hydrogen spectrum(1 H-NMR) and carbon spectrum(13 C-NMR) data.Results Twelve compounds were finally obtained from ethyl acetate of C.morifolium and the structures were identified as 5,3’,4’-trihydroxyl-3,6,7-trimethyl flavones(1),quercetin(2),artemetin(3),luteolin(4),apigenin(5),genistein-7-O-β-D-glucoside(6),apigenin-7-O-β-D-rutinoside(7),hesperetin-7-O-β-D-glucuronide(8),eriodictyol-7-O-β-D-glucoside(9),apigenin-7-O-β-D-glucoside(10),caffeic acid methylate(11),salicylis acid(12).Conclusion Compounds 1,6 were isolated from this genus for the first time,and compounds 7,8,9 were firstly isolated from C.morifolium.

关 键 词：杭白菊 化学成分 分离鉴定 

分 类 号：R284.1[医药卫生—中药学]