血清抵抗素和基质金属蛋白酶9水平对老年糖尿病患者下肢血管病变的评估价值  

Value of serum resistin and matrix metalloproteinase-9 levels in the assessment of lower extremity vascular lesions in elderly diabetic patients

作　　者：苏钢 洪娟 许继炜 廖苏丹 唐国华 Su Gang;Hong Juan;Xu Jiwei;Liao Sudan;Tang Guohua(Department of General Medicine,Wuhu No.1 People's Hospital,Wuhu 241000,Anhui,China;Department of Vascular Surgery,Wuhu No.1 People's Hospital,Wuhu 241000,Anhui,China)

机构地区：[1]芜湖市第一人民医院全科医学科,安徽芜湖241000 [2]芜湖市第一人民医院血管外科,安徽芜湖241000

出　　处：《血管与腔内血管外科杂志》2022年第7期877-880,890,共5页Journal of Vascular and Endovascular Surgery

摘　　要：目的探讨血清抵抗素和基质金属蛋白酶9(MMP9)水平对老年糖尿病患者下肢血管病变的评估价值。方法收集2018年7月至2021年7月芜湖市第一人民医院收治的107例糖尿病患者的临床资料,根据是否合并下肢血管病变将患者分为观察组(n=34,合并下肢血管病变)和对照组(n=73,未合并下肢血管病变)。比较两组患者的血清抵抗素、MMP9水平,并分析其与糖尿病患者下肢血管病变的相关性,以及糖尿病患者发生下肢血管病变的影响因素。结果观察组患者的血清抵抗素、MMP9水平均明显高于对照组患者,差异均有统计学意义(P<0.01)。相关性分析结果显示,血清抵抗素、MMP9水平与糖尿病患者下肢血管病变的发生呈正相关(r=0.586、0.450,P<0.01)。单因素分析结果显示,血清抵抗素、MMP9、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)水平及糖尿病病程、合并高血压均与糖尿病患者发生下肢血管病变有关(P<0.05)。多因素分析结果显示,糖尿病病程≥6年、合并高血压、血清抵抗素水平≥4.22 ng/ml、血清MMP9水平≥313.13μg/ml及TG、LDL-C高水平均是糖尿病患者发生下肢血管病变的危险因素(P<0.05)。受试者工作特征(ROC)曲线分析结果显示,血清抵抗素联合MMP9预测糖尿病患者发生下肢血管病变的曲线下面积明显高于MMP9单独预测的曲线下面积,差异有统计学意义(P<0.05)。结论糖尿病合并下肢血管病变患者的血清抵抗素、MMP9水平较高。血清抵抗素、MMP9水平是糖尿病患者发生下肢血管病变的影响因素,对糖尿病患者下肢血管病变的发生具有较高的评估价值。Objective To investigate the value of serum resistin and matrix metalloproteinase 9(MMP9)levels in evaluating lower extremity vascular lesions in elderly patients with diabetes.Method The clinical data of 107 diabetic patients admitted to Wuhu No.1 People's Hospital from July 2018 to July 2021 were collected,the patients were divided into observation group(n=34,with lower extremity vascular disease)and control group(n=73,without lower extremity vascular disease)according to the occurrence of lower extremity vascular disease.The levels of serum resistin and MMP9 were compared between the two groups,and the correlation between them and lower extremity vascular disease in diabetes patients was analyzed,as well as the influencing factors of lower extremity vascular disease in diabetes patients.Result The serum resistin and MMP9 levels in the observation group were significantly higher than those in the control group,the differences were statistically significant(P<0.01).The results of correlation analysis showed that serum resistin and MMP9 levels were positively correlated with the occurrence of lower extremity vascular lesions in diabetic patients(r=0.586,0.450,P<0.01).Univariate analysis showed that serum resistin,MMP9,total cholesterol(TC),triglyceride(TG),low density lipoprotein-cholesterol(LDL-C)levels,duration of diabetes,and hypertension were all associated with lower extremity vascular disease in diabetic patients(P<0.05).The results of multivariate analysis showed that the duration of diabetes≥6 years,combined with hypertension,serum resistin level≥4.22 ng/ml,serum MMP9 level≥313.13μg/ml,and high levels of TG and LDL-C were all risk factors associated with lower extremity vascular lesions in diabetic patients(P<0.05).The results of the receiver operating characteristic(ROC)curve analysis showed that the area under the curve of combined serum resistin and MMP9 to predict lower extremity vascular lesions in diabetic patients was significantly higher than that of MMP9 alone,and the difference was statis

关 键 词：糖尿病 下肢血管病变 抵抗素 基质金属蛋白酶9 评估价值 

分 类 号：R543[医药卫生—心血管疾病]