评估心力衰竭患者利尿剂抵抗理论依据和临床实践研究  

Study on theoretical basis and clinical practice of evaluating diuretic resistance in patients with heart failure

作　　者：刘建军[1] 王江红[1] 刘研 高廷廷 任燕军 LIU Jian-jun;WANG Jiang-hong;LIU Yan;GAO Ting-ting;REN Yan-jun(Department of Cardiology,the Second Hospital of Handan City,Handan 056001,China)

机构地区：[1]邯郸市第二医院心内科,河北省邯郸市056001

出　　处：《中国心血管病研究》2022年第9期854-858,共5页Chinese Journal of Cardiovascular Research

摘　　要：心力衰竭(HF)患者利尿剂抵抗(DR)虽已引起国内外普遍关注。但仍存在较多挑战性争议问题,其中包括:如何辩证理解HF钠潴留亢进机制问题;DR原因与机制;使用超常量袢利尿剂(LDs)或联合其他具有排钠作用利尿剂是缓解还是诱发DR?如何辩证理解与判断DR;DR的处理方法理论依据是否充足等。本文就上述问题提出商榷,旨降低HF患者DR及相关不良事件发生。Diuretic resistance(DR) in patients with heart failure(HF) has attracted widespread attention at home and abroad.However,there are still many challenging and controversial issues,including how to dialectically understand the mechanism of HF sodium retention hyperactivity,causes and mechanisms of DR,whether the use of extra constant loop diuretics(LDS) or other diuretics with sodium excretion alleviate or induce DR,how to understand and judge DR dialectically,whether the treatment method and theoretical basis of DR are sufficient,etc.This paper discusses the above problems in order to reduce the incidence of DR and related adverse events in patients with HF.

关 键 词：心力衰竭 限钠治疗 低钠血症 袢利尿剂 利尿剂抵抗 血管活性物质抵抗 

分 类 号：R541.6[医药卫生—心血管疾病]