体液piRNA作为疾病潜在生物标志物的研究进展  

Research progress of body fluid piRNA as a potential biomarker of disease

作　　者：邬燕倩 俞翀 沈鹭 郑浩然 洪叶挺 WU Yanqian;YU Chong;SHEN Lu;ZHENG Haoran;HONG Yeting(School of Laboratory Medicine and Bioengineering,Hangzhou Medical College,Hangzhou 311300,Zhejiang,China;Department of Urinary Surgery,the People's Hospital of Hangzhou Medical College,Hangzhou 310014,Zhejiang,China;College of Laboratory Medicine and Life Sciences,Wenzhou Medical University,Wenzhou 325035,Zhejiang,China)

机构地区：[1]杭州医学院检验医学院生物工程学院,浙江杭州311300 [2]浙江省人民医院泌尿外科,浙江杭州310014 [3]温州医科大学检验医学院生命科学院,浙江温州325035

出　　处：《检验医学》2022年第8期782-786,共5页Laboratory Medicine

基　　金：国家自然科学基金项目(81801513);浙江省高校基本科研经费资助项目(KYZD202003)。

摘　　要：PIWI蛋白相互作用RNA(piRNA)是一类可以沉默转座子及调控mRNA翻译的新型非编码小RNA。piRNA主要参与生殖细胞的发育和精子的发生,与肿瘤等疾病的发生、发展也密切相关。在特定疾病状态下,体液中的piRNA会出现差异表达,具有作为新型生物标志物的潜力。文章就体液piRNA作为各种疾病潜在的生物标志物的研究进展作一综述。PIWI-interacting RNA(piRNA)is a new class of small non-coding RNA that can silence transposon and regulate mRNA translation. Previous studies have shown that piRNA is mainly involved in germ cell development and spermatogenesis,and it is closely related to tumorigenesis and other diseases. The differential expression levels of piRNA in body fluid under specific disease states suggest that piRNA have the potential to be a new biomarker. The review focuses on the progress of research on body fluid piRNA as a potential biomarker for various diseases.

关 键 词：PIWI蛋白相互作用RNA 体液 生物标志物 

分 类 号：R446.7[医药卫生—诊断学]