白头翁汤灌肠疗法联合rhGM-CSF在宫颈癌患者放疗后放射性直肠炎中的疗效分析  

Efficacy Analysis of Baitouweng Decoction Enema Therapy Combined with rhGM-CSF in Radiation Proctitis in Patients with Cervical Cancer after Radiotherapy

作　　者：宋洪杰 SONG Hongjie(Department of Oncology,Beidahuang Group General Hospital,Harbin,Heilongjiang Province,150088 China)

机构地区：[1]北大荒集团总医院肿瘤科,黑龙江哈尔滨150088

出　　处：《世界复合医学》2022年第7期111-115,共5页World Journal of Complex Medicine

摘　　要：目的探究在宫颈癌患者放疗后放射性直肠炎中采用白头翁汤灌肠疗法联合重组人粒细胞巨噬细胞刺激因子(recombi⁃nant human granulocyte-macrophage colony stimulating factor,rhGM-CSF)的疗效。方法选取2020年4月—2021年4月于北大荒集团总医院肿瘤科治疗的宫颈癌放疗后放射性直肠炎患者96例作为研究对象,通过随机数表法将其分为对照组(n=48)和观察组(n=48)。对照组给予常规治疗联合rhGM-CSF治疗,观察组在对照组治疗的基础上给予白头翁汤灌肠治疗。对比两组患者的临床疗效、治疗前后的宫颈癌放疗后放射性直肠炎症状评分以及生活质量评分。结果观察组患者的临床有效率为91.67%,高于对照组的72.92%,差异有统计学意义(χ^(2)=5.790,P=0.016)。治疗前,两组患者症状评分比较,差异无统计学意义(t=0.172、0.448、0.164、0.105,P=0.864、0.655、0.870、0.917);治疗两周后,观察组患者症状评分低于对照组,差异有统计学意义(t=6.776、9.573、6.781、7.418,P<0.001)。治疗前,两组患者生活质量评分比较,差异无统计学意义(t=0.178,P=0.860);治疗两周后,观察组患者生活质量评分高于对照组,差异有统计学意义(t=4.945,P<0.001)。结论在宫颈癌患者放疗后放射性直肠炎中采用白头翁汤灌肠疗法联合rhGM-CSF治疗,可提高患者的临床疗效,改善患者的症状,提高其生活质量。Objective To investigate the efficacy of Baitouweng decoction enema combined with recombinant human granulocyte-macrophage colony-stimulating factor(rhGM-CSF)in patients with cervical cancer after radiation proctitis.Methods A total of 96 patients with radiation proctitis after cervical cancer radiotherapy who were treated in the Department of Oncology in Beidahuang Group General Hospital from April 2020 to April 2021 were selected as the research subjects.They were divided into control group(n=48)and observation group(n=48)by ran⁃dom number table method.The control group was given routine treatment combined with rhGM-CSF treatment,and the observation group was given Baitouweng decoction enema on the basis of the treatment of the control group.The clinical efficacy,the symptom scores of radiation proctitis after cervical cancer radiotherapy before and after treatment,and the quality of life scores were compared between the two groups.Results The clinical effective rate of patients in the observation group was 91.67%,which was higher than 72.92%in the control group,and the difference was statistically significant(χ^(2)=5.790,P=0.016).Before treatment,there was no statistically significant difference in symptom scores between the two groups of patients(t=0.172,0.448,0.164,0.105,P=0.864,0.655,0.870,0.917);after two weeks of treatment,the symptom scores of the patients in the observation group were lower than those in the control group,and the difference was statistically signifi⁃cant(t=6.776,9.573,6.781,7.418,P<0.001).Before treatment,there was no statistically significant difference in quality of life scores be⁃tween the two groups(t=0.178,P=0.860);after two weeks of treatment,the quality of life scores of patients in the observation group were higher than those in the control group,the difference was statistically significant(t=4.945,P<0.001).Conclusion Baitouweng decoction enema therapy combined with rhGM-CSF in the treatment of radiation proctitis in patients with cervical cancer after radiotherapy can im

关 键 词：宫颈癌 放射性直肠炎 白头翁汤灌肠疗法 RHGM-CSF 

分 类 号：R4[医药卫生—临床医学]