炎症反应在热射病中的作用及产生机制  

Role and mechanism of inflammatory response in heatstroke

作　　者：徐牛 姜应波[1] 耿仕涛 张松飞 赵昱凯 祝鑫 XU Niu;JIANG Ying-bo;GENG Shi-tao;ZHANG Song-fei;ZHAO Yu-kai;ZHU Xin(Department of Emergency,First Naval Hospital of Southern Theater Command,Zhanjiang,Guangdong 524000,China)

机构地区：[1]中国人民解放军南部战区海军第一医院急诊科,广东湛江524000

出　　处：《中国热带医学》2022年第6期580-584,共5页China Tropical Medicine

摘　　要：热射病(heatstroke, HS)是一种以中枢神经系统功能障碍、多器官功能衰竭和极端体温过高为特征的危及生命的疾病。随着全球气温的升高,HS发病率有所上升,尽管在治疗方面取得了很大进展,但死亡率仍很高,严重影响人类健康。数据表明,HS的病理生理变化涉及到复杂的机制,不仅受到热暴露的直接影响,还与炎症反应密切相关,但对炎症反应产生机制与炎症反应的作用认识有限。本文通过对文献的回顾,介绍了炎症反应在HS中的作用,简要阐述了细胞因子在HS中发挥作用的可能途径,重点从直接热损伤、肠黏膜屏障损伤及器官与组织损伤相关炎性因子等几个方面分析了HS炎症反应产生的可能机制,以期为进一步理解HS及基于炎症反应的治疗策略提供参考。Heatstroke(HS) is a life-threatening disorder characterized by central nervous system dysfunction,multiple organ failure,and extreme hyperthermia.With increasing temperatures worldwide,the incidence of HS has risen,and despite great advances in treatment,the mortality rate remains high,severely affecting human health.Current data suggest that complex mechanisms are involved in the pathophysiological changes in HS,which are not only directly affected by heat exposure,but also closely related to the inflammatory response.However,there is limited understanding of the mechanism and role of the inflammatory response.By reviewing the literature,this paper introduces the role of inflammatory response in HS,briefly expounds the possible ways of cytokines in HS,and focuses on the possible mechanism of inflammatory response in HS from the aspects of direct heat injury,intestinal mucosal barrier injury and inflammatory factors related to organ and tissue injury,with a view to providing further understanding of HS and therapeutic strategies based on inflammatory responses.

关 键 词：热射病 炎症反应 细胞因子 肠黏膜屏障 

分 类 号：R594.1[医药卫生—内科学]