降压药物联合草酸艾司西酞普兰治疗高血压合并焦虑抑郁患者临床疗效分析  

Clinical efficacy of antihypertensive drugs combined with escitalopram oxalate in the treatment of hypertension complicated with anxiety and depression

作　　者：赵鹏辉 周梦煜 袁成勇 Zhao Penghui;Zhou Mengyu;Yuan Chengyong(The Eighth People's Hospital of Zhengzhou City,Zhengzhou 450000,Henan,China)

机构地区：[1]郑州市第八人民医院,河南郑州450000

出　　处：《临床心身疾病杂志》2022年第5期30-34,共5页Journal of Clinical Psychosomatic Diseases

摘　　要：目的 探讨降压药物联合草酸艾司西酞普兰治疗高血压合并焦虑、抑郁患者的临床疗效。方法 将120例高血压合并焦虑、抑郁患者按照随机数字表法分为研究组与对照组,每组60例。两组均给予常规降压药物治疗,研究组联合草酸艾司西酞普兰片治疗,对照组联合心理疏导。治疗前后比较两组收缩压与舒张压水平,采用汉密顿焦虑量表及汉密顿抑郁量表评定两组焦虑抑郁情绪,比较两组临床疗效。治疗前后比较两组促甲状腺激素、游离三碘甲状腺原氨酸、游离甲状腺素水平,于治疗第2周、4周、6周末比较两组副反应量表评分,比较两组不良反应发生率。结果 治疗后两组收缩压、舒张压水平均较治疗前显著降低(P<0.01),研究组显著低于对照组(P<0.05);治疗后两组汉密顿焦虑量表、汉密顿抑郁量表评分均较治疗前显著降低(P<0.01),研究组显著低于对照组(P<0.01);研究组治疗总有效率显著高于对照组(P<0.05)。治疗后两组促甲状腺激素水平均较治疗前显著升高(P<0.01),游离三碘甲状腺原氨酸、游离甲状腺素水平均较治疗前显著降低(P<0.01),研究组较对照组变化更显著(P<0.01)。治疗第2周末研究组副反应量表评分显著高于对照组(P<0.01),治疗第4周、6周末两组副反应量表评分比较差异无统计学意义(P>0.05),两组不良反应发生率比较差异无统计学意义(P>0.05)。结论 降压药物联合草酸艾司西酞普兰治疗高血压合并焦虑、抑郁患者效果显著,可以有效控制患者血压水平,改善焦虑、抑郁情绪,安全性高。Objective To investigate the clinical efficacy of antihypertensive drugs combined with escitalopram oxalate in the treatment of hypertension complicated with anxiety and depression.Methods A total of 120 hypertensive patients with anxiety and depression were divided into study group and control group according to random number table method,with 60 cases in each group.Both groups were treated with conventional antihypertensive drugs,the study group was treated with escitalopram oxalate tablets,and the control group was treated with psychological counseling.The levels of systolic pressure(SBP)and diastolic pressure(DBP)were compared between the two groups before and after treatment.Hamilton anxiety scale(HAMA)and Hamilton depression scale(HAMD)were used to evaluate the anxiety and depression of the two groups,and the clinical effects of the two groups were compared.The levels of thyroid stimulating hormone(TSH),free triiodothyronine(FT3)and free thyroxine(FT4)were compared between the two groups before and after treatment.At the 2nd,4th,and 6th week of treatment,the treatment emergent symptom scale(TESS)scores of the two groups were compared,and the incidence of adverse reactions was compared between the two groups.Results After treatment,the levels of SBP and DBP in the two groups were significantly lower than those before treatment(P<0.01),and the study group was significantly lower than the control group(P<0.05).After treatment,the HAMAand HAMD scores of the two groups were significantly lower than those before treatment(P<0.01),and the study group was significantly lower than the control group(P<0.01).The total effective rate of treatment in the study group was significantly higher than that in the control group(P<0.05).After treatment,the levels of TSH in the two groups were significantly increased(P<0.01),and the levels of FT3 and FT4 were significantly lower than those before treatment(P<0.01),and the changes in the study group were more significant than those in the control group(P<0.01).The TESS score of t

关 键 词：高血压 焦虑 抑郁 降压药物 草酸艾司西酞普兰 

分 类 号：R544.1[医药卫生—心血管疾病]